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Theoretical study of the UVR8 protein structure, its tryptophan amino acid array and its role as a UV-B photoreceptor
National University of Ireland, Galway, Ireland.
Örebro universitet, Akademin för naturvetenskap och teknik. (Biokemi)
National University of Ireland, Galway, Ireland.
Örebro universitet, Akademin för naturvetenskap och teknik. (Biokemi)ORCID-id: 0000-0003-3315-8835
2011 (Engelska)Ingår i: UV4growth, COST-Action FA0906, 1st Annual network Meeting, Abstracts / [ed] Éva Hideg, Szeged: Biological Research Center of the Hungarian Academy of Sciences , 2011, s. 16-16Konferensbidrag, Enbart muntlig presentation (Refereegranskat)
Abstract [en]

The protein UV resistance locus 8 (UVR8) is known to be involved in the specific UV-B response resulting in regulation of a large number of genes in plants. However, the precise mechanism for the function of the protein is not yet known. We have built a homology model of the protein UVR8 from Arabidopsis thaliana, and subjected the model to energy minimization. As predicted from sequence alignments, the model has a seven-bladed β-propeller fold. The final model shows that a large amount of the highly conserved tryptophans in UVR8 are clustered on one face of the globular protein structure. After obtaining the model, a quantum chemical calculation of the excitation spectra was performed based on the structure and relative orientation of the tryptophan residues. The calculated spectrum shows two peaks, corresponding to absorption maxima around 280 and 300 nm, a result in accordance with the previous experimental studies on regulation of gene expression. In summary, the distribution of the conserved tryptophan residues in the UVR8 model, together with the involvement of these residues in the UV absorption as calculated using quantum chemical methods, suggest that UVR8 itself could act as the UV-B receptor molecule in plants absorbing at both 280 and 300 nm.

Ort, förlag, år, upplaga, sidor
Szeged: Biological Research Center of the Hungarian Academy of Sciences , 2011. s. 16-16
Nationell ämneskategori
Botanik
Forskningsämne
Biokemi
Identifikatorer
URN: urn:nbn:se:oru:diva-24336ISBN: 978-963-508-606-1 (tryckt)OAI: oai:DiVA.org:oru-24336DiVA, id: diva2:543820
Konferens
UV4growth COST-Action FA0906 1st Annual Network Meeting, Szeged, Hungary, 7-9 February 2011
Projekt
Plant UV-B photobiologyTillgänglig från: 2012-08-10 Skapad: 2012-08-10 Senast uppdaterad: 2018-05-03Bibliografiskt granskad

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Grahn, Elin M.Strid, Åke

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