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Perfluorooctane sulfonate increases β-oxidation of palmitic acid in chicken liver
Örebro universitet, Institutionen för naturvetenskap och teknik.
Örebro universitet, Institutionen för naturvetenskap och teknik.
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0001-8102-1804
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0001-7338-2079
2012 (engelsk)Inngår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 19, nr 5, s. 1859-1863Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: Perfluorooctane sulfonate (PFOS) belongs to a group of chemicals called perfluoroalkyl acids that have been extensively used in various applications such as stain and oil resistant treatments for fabrics, fire-fighting foams, and insecticides. These chemicals present an environmental and health risk being present in many samples both in wildlife and humans. In this study, we investigate the effect of PFOS on fatty acid β-oxidation in developing chicken embryos.

Methods: Fertilized chicken eggs were exposed in ovo to PFOS at day 4 of incubation. On day 10, the eggs were dissected and livers were incubated in vitro with (3)H-palmitic acid for 2 h. The media were collected, and after clean up, the amount of tritiated water was measured with liquid scintillation counting to determine the rate of palmitic acid β-oxidation.

Results: PFOS was found to induce fatty acid β-oxidation at doses starting from a lowest observed effect level (LOEL) of 0.1 μg/g egg weight. Maximum induction of 77 % compared to control was seen at 0.3 μg/g.

Conclusions: The administered doses in which effects are seen are around and even lower than the levels that can be found in wild populations of birds. General population human levels are a factor of two to three times lower than the LOEL value of this study. The environmental contamination of PFOS therefore presents a possibility of effects in wild populations of birds.

sted, utgiver, år, opplag, sider
Heidelberg, Germany: Springer Berlin/Heidelberg, 2012. Vol. 19, nr 5, s. 1859-1863
Emneord [en]
Perfluorooctane sulfonate, PFOS, exposure, chicken, palmitic acid, β-oxidation, tritium
HSV kategori
Forskningsprogram
Biologi; Biomedicinsk laboratorievetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-24853DOI: 10.1007/s11356-012-0869-1ISI: 000305884600053PubMedID: 22441698Scopus ID: 2-s2.0-84863225035OAI: oai:DiVA.org:oru-24853DiVA, id: diva2:546453
Forskningsfinansiär
Swedish Research Council FormasTilgjengelig fra: 2012-08-23 Laget: 2012-08-23 Sist oppdatert: 2017-12-07bibliografisk kontrollert
Inngår i avhandling
1. Comparative avian developmental toxicity of PFAAs
Åpne denne publikasjonen i ny fane eller vindu >>Comparative avian developmental toxicity of PFAAs
2013 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that can commonly be found in environmental matrixes and wildlife from all over the globe. The PFAAs have been used in applications such as water and dirt repelling treatments for textiles, oil-resistant paper coatings and fire-fighting foams. Four studies were designed to evaluate the occurrence of PFAAs in Swedish populations of birds, the developmental toxicity of different PFAAs and species sensitivity differences as well as possible modes of action for the toxicity. The studied species were domestic chicken, and the wild species great cormorant and herring gull. Cormorant and gull eggs were collected from bird colonies in Lake Vänern, Sweden. Chemical analyses were performed on some of the eggs to determine the occurrence of 15 PFAAs in the eggs. The other eggs and eggs of domestic chicken were incubated and injected with solutions of the PFAAs PFOS, PFOA, PFBS and PFUnDA. The eggs were candled every 1-3 days to determine viability. High levels of PFAAs, mainly PFOS followed by PFUnDA, were found in the herring gull and great cormorant eggs. PFOS was found at concentrations up to 1163 ng/g and 771 ng/g in cormorant and herring gull, respectively. In the toxicity tests, chicken was found to be more sensitive than the wild species and cormorant was in general the least sensitive species. PFOA was found to be the most toxic of the chemicals followed by PFOS, PFBS and PFUnDA in decreasing order. Comparing these results with the levels of these chemicals found in the eggs of herring gull and great cormorant, PFOS is the chemical of most concern. Although PFOA had the highest toxicity, the levels found in the eggs were very low. In an additional study, the hepatic β-oxidation in developing chicken embryos after in ovo exposure to PFOS was studied with a tritium release assay. PFOS was found to increase the β-oxidation of palmitic acid at PFOS concentrations 3-7 times lower than the average egg levels in cormorant and herring gull. Therefore the occurrence of effects on the fatty acid metabolism cannot be ruled out. The doses of effect on embryo survival in the toxicity and the levels found in the herring gulls and cormorants gives a small margin of safety for the wild populations. Continued environmental monitoring and further studies on the toxicity of PFAAs that occur at high environmental concentrations is important.

sted, utgiver, år, opplag, sider
Örebro: Örebro universitet, 2013. s. 54
Serie
Örebro Studies in Biology, ISSN 1650-8793 ; 7
Emneord
chicken, herring gull, cormorant, PFAA, PFOS, PFOA, toxicity, levels
HSV kategori
Forskningsprogram
Biologi
Identifikatorer
urn:nbn:se:oru:diva-30099 (URN)978-91-7668-959-2 (ISBN)
Disputas
2013-10-04, Hörsalen, Billbergska huset, Örebro universitet, Fakultetsgatan 1, Örebro, 13:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2013-08-01 Laget: 2013-08-01 Sist oppdatert: 2017-10-17bibliografisk kontrollert
2. Development of bioassays for risk assessment of PAHs and PFASs in the environment
Åpne denne publikasjonen i ny fane eller vindu >>Development of bioassays for risk assessment of PAHs and PFASs in the environment
2013 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro universitet, 2013. s. 72
Serie
Örebro Studies in Biology, ISSN 1650-8793 ; 8
HSV kategori
Forskningsprogram
Biologi
Identifikatorer
urn:nbn:se:oru:diva-30068 (URN)978-91-7668-965-3 (ISBN)
Disputas
2013-10-11, Hörsalen, Billbergska huset, Örebro universitet, Fakultetsgatan 1, Örebro, 10:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2013-07-30 Laget: 2013-07-30 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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