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Toward quantifying the thymic dysfunction state in mouse models of inflammatory bowel disease
School of Life Sciences, Systems Biology Research Centre, University of Skövde, Skövde, Sweden.
School of Life Sciences, Systems Biology Research Centre, University of Skövde, Skövde, Sweden.
School of Life Sciences, Systems Biology Research Centre, University of Skövde, Skövde, Sweden.
Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden.
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2013 (English)In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 19, no 4, p. 881-888Article, review/survey (Refereed) Published
Abstract [en]

Inflammatory bowel disease is characterized by a number of immunological alterations, not the least in the T-cell compartment. Numerous animal models of colitis have revealed aberrant thymocyte dynamics associated with skewed thymocyte development. The recent advancements in quantitative methods have proposed critical kinetic alterations in the thymocyte development during the progression of colitis. This review focuses on the aberrant thymocyte dynamics in Gαi2-deficient mice as this mouse model provides most quantitative data of the thymocyte development associated with colitis. Herein, we discuss several dynamic changes during the progression of colitis and propose a hypothesis for the underlying causes for the skewed proportions of the thymocyte populations seen in the Gαi2-deficient mice and in other mouse models of colitis.

Place, publisher, year, edition, pages
Philadelphia, USA: Lippincott Williams & Wilkins, 2013. Vol. 19, no 4, p. 881-888
Keywords [en]
Kinetics, thymocyte, thymus, IBD, colitis
National Category
Medical and Health Sciences Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-25591DOI: 10.1097/MIB.0b013e3182802c58ISI: 000316451600037PubMedID: 23448795Scopus ID: 2-s2.0-84884651875OAI: oai:DiVA.org:oru-25591DiVA, id: diva2:548268
Note

Funding Agencies:

Swedish Knowledge Foundation 

Swedish Research Council 

Swedish Cancer Society

Swedish Society of Medicine

Available from: 2012-08-30 Created: 2012-08-30 Last updated: 2017-12-07Bibliographically approved

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Hultgren Hörnquist, Elisabeth

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School of Medicine, Örebro University, Sweden
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