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First dating of a recombination event in mammalian tick-borne flaviviruses
Dept Plant & Environm Sci, Univ Gothenburg, Gothenburg, Sweden.
Dept Plant & Environm Sci, Univ Gothenburg, Gothenburg, Sweden.
Sch Life Sci, Södertörn Univ, Huddinge, Sweden.
Sch Life Sci, Södertörn Univ, Huddinge, Sweden; Dept Genet Microbiol & Toxicol, Stockholm Univ, Stockholm, Sweden.
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2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 2, article id e31981Article in journal (Refereed) Published
Abstract [en]

The mammalian tick-borne flavivirus group (MTBFG) contains viruses associated with important human and animal diseases such as encephalitis and hemorrhagic fever. In contrast to mosquito-borne flaviviruses where recombination events are frequent, the evolutionary dynamic within the MTBFG was believed to be essentially clonal. This assumption was challenged with the recent report of several homologous recombinations within the Tick-borne encephalitis virus (TBEV). We performed a thorough analysis of publicly available genomes in this group and found no compelling evidence for the previously identified recombinations. However, our results show for the first time that demonstrable recombination (i.e., with large statistical support and strong phylogenetic evidences) has occurred in the MTBFG, more specifically within the Louping ill virus lineage. Putative parents, recombinant strains and breakpoints were further tested for statistical significance using phylogenetic methods. We investigated the time of divergence between the recombinant and parental strains in a Bayesian framework. The recombination was estimated to have occurred during a window of 282 to 76 years before the present. By unravelling the temporal setting of the event, we adduce hypotheses about the ecological conditions that could account for the observed recombination.

Place, publisher, year, edition, pages
San Francisco: Public Library of Science , 2012. Vol. 7, no 2, article id e31981
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Microbiology in the medical area
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URN: urn:nbn:se:oru:diva-27101DOI: 10.1371/journal.pone.0031981ISI: 000302875500062PubMedID: 22384119Scopus ID: 2-s2.0-84857493482OAI: oai:DiVA.org:oru-27101DiVA, id: diva2:601439
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The Foundation for Baltic and East European StudiesAvailable from: 2013-01-29 Created: 2013-01-29 Last updated: 2019-04-04Bibliographically approved

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Melik, WessamJohansson, Magnus

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