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Colorectal cancer in patients with inflammatory bowel disease: can we predict risk?
Medical Department, Sygehus Sønderjylland Aabenraa, Aabenraa, Denmark; Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Internal Medicine, Örebro University Hospital, Örebro University, Örebro, Sweden.ORCID iD: 0000-0003-0122-7234
National Research Centre for the Working Environment, Copenhagen, Denmark.
2012 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 18, no 31, p. 4091-4094Article in journal (Refereed) Published
Abstract [en]

The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), may be complicated by colorectal cancer (CRC). In a recent population-based cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of observation. The overall risk of CRC among patients with UC and CD was comparable with that of the general population. However, patients diagnosed with UC during childhood or as adolescents, patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased risk. In this commentary, we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD patients. Further advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated CRC. The ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic IBD. The challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD patients. The achieved knowledge may also be relevant for other inflammation-associated cancers.

Place, publisher, year, edition, pages
Baishideng Publishing Group Inc. , 2012. Vol. 18, no 31, p. 4091-4094
Keywords [en]
Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Colorectal cancer; Inflammation-associated cancer; Genetics; Preventive strategies
National Category
Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-27424DOI: 10.3748/wjg.v18.i31.4091ISI: 000307986800004PubMedID: 22919240Scopus ID: 2-s2.0-84867695582OAI: oai:DiVA.org:oru-27424DiVA, id: diva2:603664
Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2017-12-06Bibliographically approved

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Halfvarson, Jonas

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