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Dietary zinc and prostate cancer survival in a Swedish cohort
Channing Lab, Dept Medicine, Brigham & Womens Hosp, Harvard University, Boston MA, USA; School of Public Health, Dept. of Epidemiology, Harvard University, Boston MA, USA.
Channing Lab, Dept Medicine, Brigham & Womens Hosp, Harvard University, Boston MA, USA; School of Public Health, Dept. of Epidemiology, Harvard University, Boston MA, USA.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Channing Lab, Dept Medicine, Brigham & Womens Hosp, Harvard University, Boston MA, USA; School of Public Health, Dept. of Epidemiology and Dept. of Nutrition, Harvard University, Boston MA, USA.
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2011 (engelsk)Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 93, nr 3, s. 586-593Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Zinc is involved in many essential cellular functions, including DNA repair and immune system maintenance. Although experimental evidence supports a role for zinc in prostate carcinogenesis, epidemiologic data are inconsistent; no data on cancer-specific survival have been reported.

Objective: Our objective was to determine whether dietary zinc assessed near the time of prostate cancer diagnosis is associated with improved disease-specific survival.

Design: This population-based cohort consists of 525 men aged < 80 y from Orebro County, Sweden, with a diagnosis of prostate cancer made between 1989 and 1994. Study participants completed self-administered food-frequency questionnaires, and zinc intake was derived from nutrient databases. Cox proportional hazards regression was used to estimate multivariate hazard ratios (HRs) and 95% CIs for time to death from prostate cancer as well as death from all causes through February 2009 by quartile (Q) of dietary zinc intake. Models were also stratified by disease stage at diagnosis (localized or advanced).

Results: With a median follow-up of 6.4 y, 218 (42%) men died of prostate cancer and 257 (49%) died of other causes. High dietary zinc intake was associated with a reduced risk of prostate cancer-specific mortality (HR(Q4 vs Q1): 0.64; 95% CI: 0.44, 0.94; P for trend = 0.05) in the study population. The association was stronger in men with localized tumors (HR: 0.24; 95% CI: 0.09, 0.66; P for trend = 0.005). Zinc intake was not associated with mortality from other causes.

Conclusion: These results suggest that high dietary intake of zinc is associated with lower prostate cancer-specific mortality after diagnosis, particularly in men with localized disease. Am J Clin Nutr 2011;93:586-93.

sted, utgiver, år, opplag, sider
2011. Vol. 93, nr 3, s. 586-593
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Identifikatorer
URN: urn:nbn:se:oru:diva-27428DOI: 10.3945/ajcn.110.004804ISI: 000287475000018OAI: oai:DiVA.org:oru-27428DiVA, id: diva2:603686
Merknad

Ove Andrén is also affiliated with  Orebro Univ Hosp, Orebro, Sweden

[ 1 ] Harvard Univ, Brigham & Womens Hosp, Channing Lab, Dept Med,Med Sch, Boston, MA 02115 USA 

[ 2 ] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

 [ 3 ] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

 [ 4 ] Orebro Univ Hosp, Orebro, Sweden 

[ 5 ] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden 

[ 6 ] Univ Uppsala Hosp, Dept Genet & Pathol, Uppsala, Sweden 

[ 7 ] Univ Iceland, Ctr Publ Hlth Serv, Reykjavik, Iceland

Tilgjengelig fra: 2013-02-06 Laget: 2013-02-06 Sist oppdatert: 2018-05-04bibliografisk kontrollert

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Andrén, OveAndersson, Swen-OlofJohansson, Jan-ErikFall, Katja

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