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Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States.
Department of Urology, Örebro University Hospital, Örebro, Sweden.
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States.
Department of Epidemiology, Harvard School of Public Health, Boston MA, United States.
Vise andre og tillknytning
2012 (engelsk)Inngår i: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 23, nr 8, s. 1359-1366Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: Recent studies suggest variation in genes along the vitamin D pathway, as well as vitamin D receptor (VDR) protein levels, may be associated with prostate cancer. As serum vitamin D levels vary by season, we sought to determine whether the expression of genes on the vitamin D pathway, assessed in prostate tumor tissue, do the same.

METHODS: Our study incorporates mRNA expression data from 362 men in the Swedish Watchful Waiting cohort, diagnosed between 1977 and 1999, and 106 men enrolled in the US Physicians' Health Study (PHS) diagnosed between 1983 and 2004. We also assayed for VDR protein expression among 832 men in the PHS and Health Professionals Follow-up Study cohorts. Season was characterized by date of initial tissue specimen collection categorically and by average monthly ultraviolet radiation levels. One-way analysis of variance was used to examine variation in the expression levels of six genes on the vitamin D pathway-VDR, GC, CYP27A1, CYP27B1, RXRα, CYP24A1-and VDR protein by season, adjusted for age at diagnosis and Gleason grade. Variation was also examined separately among lethal and nonlethal cases.

RESULTS: Tumor expression levels of the six genes did not vary significantly by season of tissue collection. No consistent patterns emerged from subgroup analyses by lethal versus nonlethal cases.

CONCLUSIONS: Unlike circulating levels of 25(OH) vitamin D, expression levels of genes on the vitamin D pathway and VDR protein did not vary overall by season of tissue collection. Epidemiological analyses of vitamin D gene expression may not be biased by seasonality.

sted, utgiver, år, opplag, sider
Springer, 2012. Vol. 23, nr 8, s. 1359-1366
Emneord [en]
Vitamin D; Vitamin D receptor; Prostate cancer; Gene expression; Seasonality; Biomarkers
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Identifikatorer
URN: urn:nbn:se:oru:diva-27799DOI: 10.1007/s10552-012-0016-9ISI: 000306122300015PubMedID: 22710747Scopus ID: 2-s2.0-84864872046OAI: oai:DiVA.org:oru-27799DiVA, id: diva2:608784
Merknad

Funding Agencies:

National Institutes of Health R25 CA098566  5 T32 CA09001-35

National Cancer Institute CA141298

Prostate Cancer Foundation

American Institute for Cancer Research

NCI/NIH P01 CA055075

Tilgjengelig fra: 2013-03-01 Laget: 2013-03-01 Sist oppdatert: 2018-05-12bibliografisk kontrollert

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