oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Expression patterns of histamine receptors in the g alpha i2-deficient mouse model of colitis
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0002-2244-9816
School of Health and Medical Science, Örebro University, Örebro, Sweden.
School of Health and Medical Science, Örebro University, Örebro, Sweden.
School of Health and Medical Science, Örebro University, Örebro, Sweden.
Show others and affiliations
2010 (English)In: Inflammation Research, ISSN 1023-3830, E-ISSN 1420-908X, Vol. 59, p. S358-S359Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Since its discovery at the beginning of the 20th century, histamine has been established to play a pathophysiological regulatory role in cellular events through binding to four types of G-protein-coupled histamine receptors that are differentially expressed in various cell types. The discovery, at the turn of the millennium, that the histamine H4 receptor is largely expressed in haemopoietic cells as well as its chemotactic properties designate its regulatory role in the immune system. H4 receptors modulate eosinophil migration and selective recruitment of mast cells leading to amplification of histamine-mediated immune responses and eventually to chronic inflammation. H4 receptor involvement in dendritic cell activation and T cell differentiation documents its immunomodulatory function. The characterization of the H4 as the immune system histamine receptor directed growing attention towards its therapeutic exploitation in inflammatory disorders, such as allergy, asthma, chronic pruritus and autoimmune diseases. The efficacy of a number of H4 receptor ligands has been evaluated in in vivo andin vitro animal models of disease and in human biological samples. However, before reaching decisive conclusions on H4 receptor pathophysiological functions and therapeutic exploitation, identification of genetic polymorphisms and interspecies differences in its relative actions and pharmacological profile need to be addressed and taken into consideration. Despite certain variations in the reported findings, the available data strongly point to the H4 receptor as a novel target for the pharmacological modulation of histamine-transferred immune signals and offer an optimistic perspective for the therapeutic exploitation of this promising new drug target in inflammatory disorders.

Place, publisher, year, edition, pages
Basel, Switzerland: Birkhauser Verlag , 2010. Vol. 59, p. S358-S359
Keywords [en]
Allergy, asthma, H4 receptor ligands, histamine, histamine H4 receptor, immune system, immunomodulation, inflammation, pruritus, rheumatoid arthritis
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-28330ISI: 000283573700073OAI: oai:DiVA.org:oru-28330DiVA, id: diva2:613829
Conference
Annual Meeting of the European-Histamine-Research-Society, JUL 13-16, 2010, Durham, ENGLAND
Available from: 2013-04-02 Created: 2013-03-14 Last updated: 2019-03-26Bibliographically approved

Open Access in DiVA

No full text in DiVA

Authority records BETA

Kumawat, Ashok K.Strid, HiljaHultgren-Hörnquist, Elisabeth

Search in DiVA

By author/editor
Kumawat, Ashok K.Strid, HiljaHultgren-Hörnquist, Elisabeth
By organisation
School of Health and Medical Sciences
In the same journal
Inflammation Research
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 360 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf