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Polycyclic aromatic hydrocarbons (PAHs) reduce hepatic beta-oxidation of fatty acids in chick embryos
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM)ORCID-id: 0000-0001-7338-2079
Örebro universitet, Hälsoakademin. (Biomedicin)ORCID-id: 0000-0001-8102-1804
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM)
Örebro universitet, Institutionen för naturvetenskap och teknik. (MTM)
Vise andre og tillknytning
2013 (engelsk)Inngår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 20, nr 3, s. 1881-1888Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Polycyclic aromatic hydrocarbons (PAHs) are widespread fused-ring contaminants formed during incomplete combustion of almost all kind of organic materials from both natural and anthropogenic sources. Some PAHs have been shown to be carcinogenic to humans, and a wide range of PAHs are found in wildlife all around the globe including avian species. The purpose of this project was to assess the effects of a standard mixture of 16 PAHs (United States Environmental Protection Agency) on the hepatic fatty acid beta-oxidation in chicken embryos (Gallus gallus domesticus) exposed in ovo. The hepatic beta-oxidation was measured using a tritium release assay with [9,10-H-3]-palmitic acid (16:0) as substrate. Treated groups were divided into groups of 0.05, 0.1, 0.3, 0.5, and 0.8 mg PAHs/kg egg weight. The hepatic beta-oxidation was reduced after exposure in ovo to the 16 PAHs mixture compared to control. The mechanisms causing reduced fatty acid oxidation in the present study are unclear, however may be due to deficient membrane structure, the functionality of enzymes controlling the rate of fatty acid entering into the mitochondria, or complex pathways connected to endocrine disruption. To the best of our knowledge, this is the first time a PAH-caused reduction of hepatic beta-oxidation of fatty acids in avian embryos has been observed. The implication of this finding on risk assessment of PAH exposure in avian wildlife remains to be determined.

sted, utgiver, år, opplag, sider
2013. Vol. 20, nr 3, s. 1881-1888
HSV kategori
Forskningsprogram
Miljövetenskap; Biologi
Identifikatorer
URN: urn:nbn:se:oru:diva-29081DOI: 10.1007/s11356-012-1418-7ISI: 000315442500065PubMedID: 23274806OAI: oai:DiVA.org:oru-29081DiVA, id: diva2:622272
Prosjekter
SOILTOX
Forskningsfinansiär
Knowledge FoundationTilgjengelig fra: 2013-05-21 Laget: 2013-05-21 Sist oppdatert: 2018-05-17bibliografisk kontrollert
Inngår i avhandling
1. Development of bioassays for risk assessment of PAHs and PFASs in the environment
Åpne denne publikasjonen i ny fane eller vindu >>Development of bioassays for risk assessment of PAHs and PFASs in the environment
2013 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro universitet, 2013. s. 72
Serie
Örebro Studies in Biology, ISSN 1650-8793 ; 8
HSV kategori
Forskningsprogram
Biologi
Identifikatorer
urn:nbn:se:oru:diva-30068 (URN)978-91-7668-965-3 (ISBN)
Disputas
2013-10-11, Hörsalen, Billbergska huset, Örebro universitet, Fakultetsgatan 1, Örebro, 10:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2013-07-30 Laget: 2013-07-30 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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