oru.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy
Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital Solna, Stockholm, Sweden; Center for Inflammatory Diseases, Karolinska Institutet, Stockholm, Sweden.
Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden.
Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital Solna, Stockholm, Sweden.
Örebro universitet, Institutionen för läkarutbildning. School of Life Sciences, Södertörns University, Stockholm, Sweden.
Vise andre og tillknytning
2013 (engelsk)Inngår i: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 68, nr 4, s. 549-552Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Patients with IgE antibodies against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to α-Gal and tick bites. We provide the first direct evidence that α-Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization to α-Gal, with development of red meat allergy as a secondary phenomena. Serum from Swedish patients with delayed severe reactions to red meat was included in the study. A dose-dependent inhibition of IgE responses to α-Gal by the tick Ixodes ricinus is demonstrated. Furthermore, using cryostat-cut sections of I. ricinus, we show that both a monoclonal and a polyclonal antibody against α-Gal stains the gastrointestinal tract of the tick. The same pattern is seen when staining with patient sera IgE positive to α-Gal. These results confirm that the α-Gal epitope is present in I. ricinus and imply host exposure to α-Gal during a tick bite. This provides further evidence that tick bites are associated with IgE responses to α-Gal and red meat allergy.

sted, utgiver, år, opplag, sider
West Sussex, United Kingdom: Wiley-Blackwell Publishing Inc., 2013. Vol. 68, nr 4, s. 549-552
Emneord [en]
Galactose-α-1, 3-galactose, IgE, red meat allergy, ticks
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-30277DOI: 10.1111/all.12128ISI: 000316323600020PubMedID: 23414348Scopus ID: 2-s2.0-84875432304OAI: oai:DiVA.org:oru-30277DiVA, id: diva2:642369
Forskningsfinansiär
Swedish Research CouncilStockholm County CouncilSwedish Heart Lung FoundationSwedish Asthma and Allergy Association
Merknad

Fundig Agency:

Center for Inflammatory Diseases Karolinska Institutet 

Swedish Cancer- and Allergy Foundation 

Konsul ThBergs Foundation 

King Gustaf V 80th Birthday Foundation 

Hesselman Foundation and Karolinska Institutet 

Tilgjengelig fra: 2013-08-21 Laget: 2013-08-21 Sist oppdatert: 2018-05-21bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Johansson, Magnus

Søk i DiVA

Av forfatter/redaktør
Johansson, Magnus
Av organisasjonen
I samme tidsskrift
Allergy. European Journal of Allergy and Clinical Immunology

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 546 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf