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Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy
Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital Solna, Stockholm, Sweden; Center for Inflammatory Diseases, Karolinska Institutet, Stockholm, Sweden.
Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden.
Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital Solna, Stockholm, Sweden.
Örebro universitet, Institutionen för läkarutbildning. School of Life Sciences, Södertörns University, Stockholm, Sweden.
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2013 (Engelska)Ingår i: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 68, nr 4, s. 549-552Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Patients with IgE antibodies against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to α-Gal and tick bites. We provide the first direct evidence that α-Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization to α-Gal, with development of red meat allergy as a secondary phenomena. Serum from Swedish patients with delayed severe reactions to red meat was included in the study. A dose-dependent inhibition of IgE responses to α-Gal by the tick Ixodes ricinus is demonstrated. Furthermore, using cryostat-cut sections of I. ricinus, we show that both a monoclonal and a polyclonal antibody against α-Gal stains the gastrointestinal tract of the tick. The same pattern is seen when staining with patient sera IgE positive to α-Gal. These results confirm that the α-Gal epitope is present in I. ricinus and imply host exposure to α-Gal during a tick bite. This provides further evidence that tick bites are associated with IgE responses to α-Gal and red meat allergy.

Ort, förlag, år, upplaga, sidor
West Sussex, United Kingdom: Wiley-Blackwell Publishing Inc., 2013. Vol. 68, nr 4, s. 549-552
Nyckelord [en]
Galactose-α-1, 3-galactose, IgE, red meat allergy, ticks
Nationell ämneskategori
Medicin och hälsovetenskap Gastroenterologi
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-30277DOI: 10.1111/all.12128ISI: 000316323600020PubMedID: 23414348Scopus ID: 2-s2.0-84875432304OAI: oai:DiVA.org:oru-30277DiVA, id: diva2:642369
Forskningsfinansiär
VetenskapsrådetStockholms läns landstingHjärt-LungfondenAstma- och Allergiförbundet
Anmärkning

Fundig Agency:

Center for Inflammatory Diseases Karolinska Institutet 

Swedish Cancer- and Allergy Foundation 

Konsul ThBergs Foundation 

King Gustaf V 80th Birthday Foundation 

Hesselman Foundation and Karolinska Institutet 

Tillgänglig från: 2013-08-21 Skapad: 2013-08-21 Senast uppdaterad: 2018-05-21Bibliografiskt granskad

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Johansson, Magnus

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Allergy. European Journal of Allergy and Clinical Immunology
Medicin och hälsovetenskapGastroenterologi

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