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Reduced T cell receptor excision circle levels in the colonic mucosa of microscopic colitis patients indicate local proliferation rather than homing of peripheral lymphocytes to the inflamed mucosa
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.ORCID iD: 0000-0002-2244-9816
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
Örebro University, School of Health and Medical Sciences. Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Region Örebro County, Örebro, sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
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2013 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 408638Article in journal (Refereed) Published
Abstract [en]

Dysregulated T cell responses in the intestine may lead to chronic bowel inflammation such as collagenous colitis (CC) and lymphocytic colitis (LC), together known as microscopic colitis (MC). Having demonstrated increased local T cell responses in the intestinal mucosa of MC patients, we investigated the recent thymic emigrants by measuring T cell receptor excision circle (TREC) levels in the colonic biopsies from CC (n = 8), LC (n = 5), and CC or LC patients in histopathological remission (CC-HR, n = 3) (LC-HR, n = 6), non-inflamed diarrhoea patients (n = 17), and controls (n = 10) by real-time PCR. We observed lower median TREC levels in both CC and LC patients as well as in LC-HR patients compared to controls. In contrast to MC patients, non-inflamed diarrhoea patients presented with enhanced TREC levels compared to controls. None of the recorded differences did, however, reach statistical significance. A trend towards increased relative expression of CD3 was noted in all MC subgroups examined and reached statistical significance in LC patients compared to controls. In conclusion, reduced TRECs level in the colonic mucosa, together with our previously demonstrated enhanced expression of Ki67(+) T cells, suggests local expansion of resident T lymphocytes in the inflamed mucosa of MC patients.

Place, publisher, year, edition, pages
New York, USA: Hindawi Publishing Corporation, 2013. article id 408638
National Category
Medical and Health Sciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-30733DOI: 10.1155/2013/408638ISI: 000323011000001PubMedID: 23956982Scopus ID: 2-s2.0-84883171227OAI: oai:DiVA.org:oru-30733DiVA, id: diva2:646072
Note

Funding Agencies:

Swedish Society of Medicine (Bengt Ihre Foundation) 

Örebro University Hospital Research Foundation

Available from: 2013-09-06 Created: 2013-09-06 Last updated: 2019-03-26Bibliographically approved

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Kumawat, Ashok KumarElgbratt, KristinaTysk, CurtBohr, JohanHultgren-Hörnquist, Elisabeth

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Kumawat, Ashok KumarElgbratt, KristinaTysk, CurtBohr, JohanHultgren-Hörnquist, Elisabeth
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School of Health and Medical Sciences, Örebro University, SwedenSchool of Health and Medical SciencesÖrebro University HospitalSchool of Medicine, Örebro University, Sweden
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BioMed Research International
Medical and Health SciencesMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Gastroenterology and Hepatology

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