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The new variant of Chlamydia trachomatis was present as early as 2003 in Orebro County, Sweden, but remained undetected until 2006
Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro University Hospital, Örebro, Sweden.ORCID-id: 0000-0003-1710-2081
2013 (Engelska)Ingår i: Sexually Transmitted Infections, ISSN 1368-4973, E-ISSN 1472-3263, Vol. 89, nr 7, s. 607-608Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives In 2006, a new variant of Chlamydia trachomatis (nvCT) was reported in Sweden. Because of a cryptic plasmid deletion, the nvCT was undetectable in several of the genetic diagnostic systems used worldwide at the time. This study aimed to evaluate whether the nvCT was present in specimens obtained from patients attending the outpatient sexually transmitted infection (STI) clinic at orebro University Hospital, orebro, Sweden already in 2002-2003. Methods In 2012, archival (-20 degrees C freezer) urogenital specimens (2002 (n=1083) and in 2003 (n=1143)) obtained from men (2002 (n=398) and 2003 (n=486)) and women (2002 (n=301) and 2003 (n=408)) were analysed with Cobas TaqMan CT test V.2.0. All C trachomatis positive specimens were subsequently examined using a duplex PCR assay that simultaneously detects the deletion on the nvCT cryptic plasmid and the ompA gene of C trachomatis genotype E. Results In total, 68 patients (9.7%) in 2002 and 61 (6.8%) in 2003 were C trachomatis positive. The duplex PCR assay identified 26 C trachomatis genotype E positive patients in 2002 (38%) and 25 in 2003 (41%). No nvCT was found in 2002, but one specimen obtained from a 23-year-old man in June 2003 was positive for the nvCT. Conclusions The nvCT was present as early as 2003 in orebro County, Sweden, which concurs with previously reported statistical estimations of its emergence. Accordingly, the nvCT spread undetected for at least 3years, explaining the high proportion (38%) in orebro County when it was first detected in late 2006.

Ort, förlag, år, upplaga, sidor
2013. Vol. 89, nr 7, s. 607-608
Nyckelord [en]
Chlamydia Trachomatis, Epidemiology (General), Diagnosis
Nationell ämneskategori
Infektionsmedicin
Forskningsämne
Infektionssjukdomar
Identifikatorer
URN: urn:nbn:se:oru:diva-32360DOI: 10.1136/sextrans-2013-051018ISI: 000325542900020Scopus ID: 2-s2.0-84891555025OAI: oai:DiVA.org:oru-32360DiVA, id: diva2:664225
Tillgänglig från: 2013-11-14 Skapad: 2013-11-12 Senast uppdaterad: 2024-01-11Bibliografiskt granskad

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Jurstrand, MargarethaFredlund, HansUnemo, Magnus

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Jurstrand, MargarethaFredlund, HansUnemo, Magnus
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Institutionen för hälsovetenskap och medicinRegion Örebro län
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