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Disproportionate Body Composition and Neonatal Outcome in Offspring of Mothers With and Without Gestational Diabetes Mellitus
Karolinska Institute, Stockholm, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0002-2691-7525
Uppsala University, Uppsala, Sweden.
Kings College London, London, England.
2013 (Engelska)Ingår i: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 36, nr 11, s. 3543-3548Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE High birth weight is a risk factor for neonatal complications. It is not known if the risk differs with body proportionality. The primary aim of this study was to determine the risk of adverse pregnancy outcome in relation to body proportionality in large-for-gestational-age (LGA) infants stratified by maternal gestational diabetes mellitus (GDM).

RESEARCH DESIGN AND METHODSPopulation-based study of all LGA (birth weight [BW] >90th percentile) infants born to women with GDM (n = 1,547) in 1998-2007. The reference group comprised LGA infants (n = 83,493) born to mothers without diabetes. Data were obtained from the Swedish Birth Registry. Infants were categorized as proportionate (P-LGA) if ponderal index (PI) (BW in grams/length in cm(3)) was 90th percentile and as disproportionate (D-LGA) if PI >90th percentile. The primary outcome was a composite morbidity: Apgar score 0-3 at 5 min, birth trauma, respiratory disorders, hypoglycemia, or hyperbilirubinemia. Logistic regression analysis was used to obtain odds ratios (ORs) for adverse outcomes.

RESULTSThe risk of composite neonatal morbidity was increased in GDM pregnancies versus control subjects but comparable between P- and D-LGA in both groups. D-LGA infants born to mothers without diabetes had significantly increased risk of birth trauma (OR 1.19 [95% CI 1.09-1.30]) and hypoglycemia (1.23 [1.11-1.37]). D-LGA infants in both groups had significantly increased odds of Cesarean section.

CONCLUSIONSThe risk of composite neonatal morbidity is significantly increased in GDM offspring. In pregnancies both with and without GDM, the risk of composite neonatal morbidity is comparable between P- and D-LGA.

Ort, förlag, år, upplaga, sidor
2013. Vol. 36, nr 11, s. 3543-3548
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-32623DOI: 10.2337/dc13-0899ISI: 000326274100032OAI: oai:DiVA.org:oru-32623DiVA, id: diva2:675745
Anmärkning

Funding Agency: Samariten Foundation; Stockholm City Council; National Institute for Health Research, U.K; Tommy's Charity, U.K.

Tillgänglig från: 2013-12-04 Skapad: 2013-12-04 Senast uppdaterad: 2019-04-24Bibliografiskt granskad

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Fadl, HelenaHanson, Ulf

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