oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Increased prevalence of antibodies against dietary proteins in children and young adults with cerebral palsy
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
Dept. Clinical and Experimental Medicine, Clinical Immunology, Linköping University, Linköping, Sweden.
Clinical Epidemiology and Biostatistic Unit, Örebro University Hospital, Örebro, Sweden .
Centre for Clinical Research, Falun, Sweden .
Show others and affiliations
2013 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 56, no 2, p. 233-8Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Undernourishment is common in children with cerebral palsy (CP), but the reasons are unknown. We previously reported elevated levels of immunoglobulin (Ig) A and IgG antibodies against gliadin (AGA) and tissue transglutaminase (tTG) in 99 children and young adults with CP without characteristic findings of gluten enteropathy in small bowel biopsies. Our aim was to perform a case-control study of IgG antibodies against other dietary antigens, AGA, anti-tTG, and IgE antibodies against wheat and gluten.

METHODS: Sera from 99 cases with CP and 99 healthy, age- and sex-matched controls were analysed with fluorescence enzyme-linked immunosorbent assay for detection of IgG antibodies against β-lactoglobulin, casein, egg white, IgG- and IgA-AGA, IgA-anti-tTG, and IgE antibodies against gluten and wheat.

RESULTS: Compared with controls, the odds ratio in cases with CP for having elevated levels of IgG antibodies against β-lactoglobulin was 17.0 (95% confidence interval [CI] 2.3-128), against casein 11.0 (95% CI 2.6-46.8), and against egg white 7.0 (95% CI 1.6-30.8). The IgE responses for wheat/gluten were generally low. The tetraplegic and dyskinetic CP subtypes had significantly higher frequencies of elevated levels for all of the tested antibodies except IgG against egg white, and IgA-anti-tTG. A significantly lower weight was seen in cases with CP with positive versus negative serology.

CONCLUSIONS: Elevated levels of IgG against dietary antigens were more frequent in the CP group compared with controls, and particularly in the tetraplegic and dyskinetic CP subtypes with the most severe neurologic handicap and undernourishment. Hypothetically, malnourishment may cause increased intestinal permeability and thus immunization against dietary antigens.

Place, publisher, year, edition, pages
2013. Vol. 56, no 2, p. 233-8
Keywords [en]
Adolescent, Adult, Antibodies, Autoantibodies, Body Weight, Case-Control Studies, Caseins, Celiac Disease, Cerebral Palsy, Child, Child, Preschool, Dietary Proteins, Egg White, Female, Glutens, Humans, Immunoglobulin A, Immunoglobulin E, Immunoglobulin G, Infant, Lactoglobulins, Male, Malnutrition, Transglutaminases, Triticum, Young Adult
National Category
Gastroenterology and Hepatology Nutrition and Dietetics Pediatrics
Research subject
Internal Medicine; Pediatrics; Nutrition
Identifiers
URN: urn:nbn:se:oru:diva-33885DOI: 10.1097/MPG.0b013e318272cbf4ISI: 000314099600031PubMedID: 22983381Scopus ID: 2-s2.0-84873055288OAI: oai:DiVA.org:oru-33885DiVA, id: diva2:698286
Note

Funding agencies are:

Research Committee of Orebro County Council  

Folke Bernadotte Foundation, Stockholm, Sweden 

Available from: 2014-02-21 Created: 2014-02-21 Last updated: 2018-05-22Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Stenberg, ReidunTysk, Curt

Search in DiVA

By author/editor
Stenberg, ReidunTysk, Curt
By organisation
School of Health and Medical Sciences, Örebro University, SwedenÖrebro University Hospital
In the same journal
Journal of Pediatric Gastroenterology and Nutrition - JPGN
Gastroenterology and HepatologyNutrition and DieteticsPediatrics

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 473 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf