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Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses
Örebro universitet, Institutionen för naturvetenskap och teknik. Örebro Life Sci Ctr, Univ Örebro, Örebro, Sweden; Sch Sci & Technol, Univ Örebro, Örebro, Sweden.
Swedish Institute for Communicable Disease Control (SMI), Stockholm, Sweden.
Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden.
Örebro universitet, Institutionen för naturvetenskap och teknik. Örebro Life Sci Ctr, Univ Örebro, Örebro, Sweden. (Biokemi)
Vise andre og tillknytning
2014 (engelsk)Inngår i: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 32, nr 20, s. 2288-2293Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

During early infection with human immunodeficiency virus type 1 (HIV-1), there is a rapid depletion of CD4+ T-cells in the gut-associated lymphoid tissue (GALT) in the gastrointestinal tract. Therefore, immediate protection at these surfaces is of high priority for the development of an HIV-1 vaccine. Thus, transgenic plants expressing HIV-1 antigens, which are exposed to immune competent cells in the GALT during oral administration, can be interesting as potential vaccine candidates. In the present study, we used two HIV-1 p24 antigen-expressing transgenic plant systems, Arabidopsis thaliana and Daucus carota, in oral immunization experiments. Both transgenic plant systems showed a priming effect in mice and induced humoral immune responses, which could be detected as anti-p24-specific IgG in sera after an intramuscular p24 protein boost. Dose-dependent antigen analyses using transgenic Arabidopsis thaliana indicated that low p24 antigen doses were superior to high p24 antigen doses

sted, utgiver, år, opplag, sider
Elsevier, 2014. Vol. 32, nr 20, s. 2288-2293
Emneord [en]
Transgenic plants; Arabidopsis thaliana; Carrot; Edible vaccine; Oral immunization; HIV-1 p24
HSV kategori
Forskningsprogram
Biokemi; Immunologi
Identifikatorer
URN: urn:nbn:se:oru:diva-33982DOI: 10.1016/j.vaccine.2014.02.073ISI: 000335100600005PubMedID: 24631072Scopus ID: 2-s2.0-84897502968OAI: oai:DiVA.org:oru-33982DiVA, id: diva2:699465
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Ätbara vacciner
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Knowledge Foundation
Merknad

Funding Agencies:

Örebro University's Faculty for Business, Science, and Technology 

Nyckelfonden

Tilgjengelig fra: 2014-02-27 Laget: 2014-02-27 Sist oppdatert: 2018-06-05bibliografisk kontrollert

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Lindh, IngridHadad, RonzaKalbina, IrinaStrid, ÅkeAndersson, Sören

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