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Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section
Dept Preparedness, Swedish Inst Communicable Dis Control, Solna, Sweden; Dept Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden.
Div Pediat, Dept Clin & Expt Med, Linköping Univ, Linköping, Sweden.
Div Inflammat Med, Dept Clin & Expt Med, Linköping Univ, Linköping, Sweden.
School of Engineering, Univ Glasgow, Glasgow, UK.
Vise andre og tillknytning
2014 (engelsk)Inngår i: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 63, nr 4, s. 559-566Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective The early intestinal microbiota exerts important stimuli for immune development, and a reduced microbial exposure as well as caesarean section (CS) has been associated with the development of allergic disease. Here we address how microbiota development in infants is affected by mode of delivery, and relate differences in colonisation patterns to the maturation of a balanced Th1/Th2 immune response.

Design The postnatal intestinal colonisation pattern was investigated in 24 infants, born vaginally (15) or by CS (nine). The intestinal microbiota were characterised using pyrosequencing of 16S rRNA genes at 1 week and 1, 3, 6, 12 and 24 months after birth. Venous blood levels of Th1- and Th2-associated chemokines were measured at 6, 12 and 24 months.

Results Infants born through CS had lower total microbiota diversity during the first 2 years of life. CS delivered infants also had a lower abundance and diversity of the Bacteroidetes phylum and were less often colonised with the Bacteroidetes phylum. Infants born through CS had significantly lower levels of the Th1-associated chemokines CXCL10 and CXCL11 in blood.

Conclusions CS was associated with a lower total microbial diversity, delayed colonisation of the Bacteroidetes phylum and reduced Th1 responses during the first 2 years of life.

sted, utgiver, år, opplag, sider
London: BMJ Publishing Group , 2014. Vol. 63, nr 4, s. 559-566
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-35355DOI: 10.1136/gutjnl-2012-303249ISI: 000332267500006OAI: oai:DiVA.org:oru-35355DiVA, id: diva2:724637
Forskningsfinansiär
Swedish Research CouncilSwedish Research Council Formas
Merknad

Funding Agencies:

Ekhaga Foundation and the Soderbergs Foundation

Research Council for the South-East Sweden

Swedish Asthma and Allergy Association

Olle Engkvist Foundation

Vardal Foundation-for Health Care Sciences and Allergy Research

Swedish Research Councils VR

Unilever

Tilgjengelig fra: 2014-06-13 Laget: 2014-06-13 Sist oppdatert: 2018-09-06bibliografisk kontrollert

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