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Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0003-4713-1772
Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro universitet, Institutionen för läkarutbildning.ORCID-id: 0000-0003-3383-9219
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0002-2244-9816
Örebro universitet, Institutionen för läkarutbildning.ORCID-id: 0000-0001-5460-8888
Vise andre og tillknytning
2014 (engelsk)Inngår i: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 49, nr 9, s. 1068-1075Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Irritable bowel syndrome (IBS) is characterized by chronic abdominal symptoms such as pain, discomfort, and altered bowel habits. A subset of IBS patients, denoted as post-infectious IBS (PI-IBS) patients, develop symptoms after an enteric infection. Distinct abnormalities in the gut mucosa, including mucosal inflammation, have been proposed to contribute to or be the cause of PI-IBS. This study investigated lymphocyte subsets in PI-IBS patients compared to healthy controls.

Materials and methods: Ten PI-IBS patients and nine healthy controls participated. All PI-IBS patients met the Rome III diagnostic criteria for IBS and reported sustained symptoms at least 1 year after an episode of acute gastroenteritis. Intraepithelial lymphocytes and lamina propria lymphocytes (LPLs), isolated from mucosal tissue samples, were stained and analyzed for a comprehensive set of cell markers using flow cytometry.

Results: The number of LPLs in PI-IBS was significantly increased compared to those in healthy controls (p < 0.05). PI-IBS patients showed significantly increased proportions of CD45RO(+) CD4(+) activated/memory T cells (p < 0.05) and double-positive CD4(+) CD8(+) cells (p < 0.05), respectively, in the lamina propria. The number of CD19(+) LPLs was decreased in PI-IBS patients compared to healthy controls (p < 0.001).

Conclusion: This study presents new evidence that PI-IBS is associated with a sustained aberrant mucosal immune response and support future studies of anti-inflammatory or immune-modulating treatments in these patients.

sted, utgiver, år, opplag, sider
Informa Healthcare, 2014. Vol. 49, nr 9, s. 1068-1075
Emneord [en]
cell biology, gastrointestinal, infections, health economy, immunology
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-35383DOI: 10.3109/00365521.2014.926982ISI: 000340829900006PubMedID: 24919810Scopus ID: 2-s2.0-84906318425OAI: oai:DiVA.org:oru-35383DiVA, id: diva2:725759
Merknad

Funding Agency:

Medical Faculty, Örebro University

Tilgjengelig fra: 2014-06-17 Laget: 2014-06-17 Sist oppdatert: 2019-03-26bibliografisk kontrollert
Inngår i avhandling
1. Microbe-host interactions in post-infectious irritable bowel syndrome
Åpne denne publikasjonen i ny fane eller vindu >>Microbe-host interactions in post-infectious irritable bowel syndrome
2015 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2015. s. 97
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 114
Emneord
IBS, PI-IBS, Intestinal, Mucosa, Lymphocyte, Microbiota, Bacteria, Cytokine, Addaptive immune response, IL-13
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
urn:nbn:se:oru:diva-41109 (URN)978-91-7529-057-7 (ISBN)
Disputas
2015-02-27, Prismahuset, Hörsal 2, Örebro universitet, Fakultetsgatan 1, Örebro, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2015-01-13 Laget: 2015-01-13 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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Sundin, JohannaRangel, IgnacioKumawat, Ashok KHultgren-Hörnquist, ElisabethBrummer, Robert J

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