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Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters
Örebro universitet, Institutionen för naturvetenskap och teknik.
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0003-3302-7106
Örebro universitet, Institutionen för naturvetenskap och teknik.
Örebro universitet, Institutionen för naturvetenskap och teknik.
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2014 (engelsk)Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 488-489, s. 228-235Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the observed levels. In addition to chemical pollutants, there is also a concern for increasing levels of bacteria and other microorganisms in freshwater systems. In an earlier study, we observed the activation of inflammatory systems downstream of a wastewater treatment plant (WWTP) in southern Sweden. We also observed that the water contained unidentified components that were pro-inflammatory and potentiated the immune response in human urinary bladder epithelial cells. In order to determine if these effects were unique for the studied site or represent a common response in Swedish water, we have now performed a study on three WWTPs and their recipient waters in central Sweden. Analysis of immune responses in urinary bladder epithelial cells, monocyte-like cells and blood mononuclear cells confirm that these waters activate the immune system as well as induce pro-inflammatory responses. The results indicate that the cytokine profiles correlate to the endotoxin load of the waters rather than to the levels of pharmaceuticals or culturable bacteria load, suggesting that measurements of endotoxin levels and immune responses would be a valuable addition to the analysis of inland waters.

sted, utgiver, år, opplag, sider
Elsevier, 2014. Vol. 488-489, s. 228-235
Emneord [en]
Wastewater treatment plants; Immune response; Cytokines; Bacteria; Inflammation; Pharmaceuticals
HSV kategori
Forskningsprogram
Miljövetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-35474DOI: 10.1016/j.scitotenv.2014.04.090ISI: 000338600800023PubMedID: 24836131Scopus ID: 2-s2.0-84900490429OAI: oai:DiVA.org:oru-35474DiVA, id: diva2:728312
Forskningsfinansiär
Knowledge Foundation
Merknad

Funding Agencies:

City of Örebro

Karlskoga Energi och Miljö AB

Mälarenergi AB

Pelagia Miljökonsult AB

Tyrens AB

Örebro University

Tilgjengelig fra: 2014-06-24 Laget: 2014-06-24 Sist oppdatert: 2019-01-10bibliografisk kontrollert

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Elmarghani, AhmedPradhan, AjaySeyoum, AsmeromKhalaf, HazemJass, JanaOlsson, Per-Erik

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