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Long-term molecular epidemiology of staphylococcus epidermidis blood culture isolates from patients with hematological malignancies
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Department of Medicine, Division of Hematology, Örebro University Hospital, Örebro, Sweden.
Region Örebro län. Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för läkarutbildning. Region Örebro län. Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.ORCID-id: 0000-0001-5939-2932
2014 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, nr 6, artikel-id e99045Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Staphylococcus epidermidis is an important cause of bloodstream infections in patients with hematological malignancies. Knowledge of the long-term epidemiology of these infections is limited. We surveyed all S. epidermidis blood culture isolates from patients treated for hematological malignancies at the University Hospital of Orebro, Sweden from 1980 to 2009. A total of 373 S. epidermidis isolates were identified and multilocus sequence typing, staphylococcal chromosome cassette mec (SCCmec) typing and standard antibiotic susceptibility testing were employed to characterize these isolates. The majority of the isolates 361/373 (97%) belonged to clonal complex 2, and the 373 isolates were divided into 45 sequence types (STs); Simpson's Diversity Index was 0.56. The most prevalent STs were ST2 (243/373, 65%) and ST215 (28/373, 8%). Ninety three percent (226/243) of the ST2 isolates displayed either SCCmec type III or IV. ST2 and 215 were isolated during the entire study period, and together these STs caused temporal peaks in the number of positive blood cultures of S. epidermidis. Methicillin resistance was detected in 213/273 (78%) of all isolates. In the two predominating STs, ST2 and ST215, methicillin resistance was detected in 256/271 isolates (95%), compared with 34/100 (34%) in other STs (p<0.001). In conclusion, in this long-term study of patients with hematological malignancies, we demonstrate a predominance of methicillin-resistant ST2 among S. epidermidis blood culture isolates.

Ort, förlag, år, upplaga, sidor
San Francisco, USA: Public Library Science , 2014. Vol. 9, nr 6, artikel-id e99045
Nationell ämneskategori
Medicin och hälsovetenskap Infektionsmedicin
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-36178DOI: 10.1371/journal.pone.0099045ISI: 000338430700108PubMedID: 24896826Scopus ID: 2-s2.0-84902504044OAI: oai:DiVA.org:oru-36178DiVA, id: diva2:742632
Anmärkning

Funding Agency:

Örebro county council research committee at the Örebro University Hospital, Sweden

Tillgänglig från: 2014-09-02 Skapad: 2014-08-28 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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Ahlstrand, ErikHellmark, BengtSöderquist, Bo

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Institutionen för hälsovetenskap och medicinRegion Örebro länInstitutionen för läkarutbildning
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