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AEG-1 expression is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy: a study in a Swedish clinical trial
County Council of Östergötland, Linköping, Sweden; University of Linköping, Linköping, Sweden.
Örebro universitet, Institutionen för läkarutbildning.
County Council of Östergötland, Linköping, Sweden; University of Linköping, Linköping, Sweden.
Linköping University, Linköping, Sweden.
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2014 (Engelska)Ingår i: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 111, nr 1, s. 166-173Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Preoperative radiotherapy (RT) is widely used to downstage rectal tumours, but the rate of recurrence varies significantly. Therefore, new biomarkers are needed for better treatment and prognosis. It has been shown that astrocyte elevated gene-1 (AEG-1) is a key mediator of migration, invasion, and treatment resistance. Our aim was to analyse the AEG-1 expression in relation to RT in rectal cancer patients and to test its radiosensitising properties.

Methods: The AEG-1 expression was examined by immunohistochemistry in 158 patients from the Swedish clinical trial of RT. Furthermore, we inhibited the AEG-1 expression by siRNA in five colon cancer cell lines and measured the survival after irradiation by colony-forming assay.

Results: The AEG-1 expression was increased in the primary tumours compared with the normal mucosa independently of the RT (P<0.01). High AEG-1 expression in the primary tumour of the patients treated with RT correlated independently with higher risk of distant recurrence (P = 0.009) and worse disease-free survival (P = 0.007). Downregulation of AEG-1 revealed a decreased survival after radiation in radioresistant colon cancer cell lines.

Conclusions: The AEG-1 expression was independently related to distant recurrence and disease-free survival in rectal cancer patients with RT and could therefore be a marker to discriminate patients for distant relapse.

Ort, förlag, år, upplaga, sidor
London, United Kingdom: Nature Publishing Group, 2014. Vol. 111, nr 1, s. 166-173
Nyckelord [en]
MTDH, astrocyte elevated gene-1, distant recurrence, disease-free survival
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
Onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-36172DOI: 10.1038/bjc.2014.250ISI: 000339163300020PubMedID: 24874474Scopus ID: 2-s2.0-84904092088OAI: oai:DiVA.org:oru-36172DiVA, id: diva2:742661
Forskningsfinansiär
CancerfondenVetenskapsrådet
Anmärkning

Funding Agency:

Health Research Council in South-East Sweden

Tillgänglig från: 2014-09-02 Skapad: 2014-08-28 Senast uppdaterad: 2017-12-05Bibliografiskt granskad

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Zhang, Hong

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