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Electroporation therapy of skin cancer in the head and neck area.
Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för läkarutbildning. Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
Department of Oncology, Örebro University Hospital, Örebro, Sweden.
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2010 (Engelska)Ingår i: Dermatologic Surgery, ISSN 1076-0512, E-ISSN 1524-4725, Vol. 36, nr 8, s. 1245-50Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Electroporation therapy is a new cancer treatment modality in which a locally applied electrical field enhances cell membrane permeability, allowing greater intracellular accumulation of a chemotherapeutic agent.

OBJECTIVE: To evaluate the efficacy of electroporation therapy in treating basal cell and squamous cell carcinomas of the skin.

MATERIALS AND METHODS: Six patients with skin cancer of the head and neck were treated using electroporation therapy with intratumorally injected bleomycin. Orbital growth, facial nerve proximity, or proximity to cartilage of the external meatus complicated four of these tumors. The intention was curative. The follow-up period was 24 months and included biopsies after 8 weeks.

RESULTS: In four of the six patients, one treatment was enough to eradicate the tumor. In one patient, the tumor persisted even after a second treatment with electroporation therapy. A septal cartilage perforation was the only major complication. The cosmetic results were very satisfactory. One additional recurrence was recorded 6 months after the follow-up period

CONCLUSION: Electroporation therapy is a promising new cancer treatment that should be further evaluated as an alternative to surgery, especially in complicated skin cancer.

Ort, förlag, år, upplaga, sidor
2010. Vol. 36, nr 8, s. 1245-50
Nyckelord [en]
Electroporation therapy, tumor control, basal cell carcinoma, squamous cell carcinoma, BCC, SCC
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
Onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-37223DOI: 10.1111/j.1524-4725.2010.01617.xISI: 000280457400005PubMedID: 20666812Scopus ID: 2-s2.0-77955152383OAI: oai:DiVA.org:oru-37223DiVA, id: diva2:750554
Anmärkning

Funding agencies:

Orebro County Council  

Inovio Biomedical Corporation  

Genetronics, Inc. 

Genetronics, Inc. provided financial support for this study and has paid Dr. L. Lofgren an honorarium forwork at investigator meetings.

Tillgänglig från: 2014-09-29 Skapad: 2014-09-29 Senast uppdaterad: 2017-12-05Bibliografiskt granskad
Ingår i avhandling
1. Curative electrochemotherapy in the head and neck area
Öppna denna publikation i ny flik eller fönster >>Curative electrochemotherapy in the head and neck area
2015 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Ort, förlag, år, upplaga, sidor
Örebro: Örebro university, 2015. s. 94
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 117
Nationell ämneskategori
Kirurgi
Forskningsämne
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-42215 (URN)978-91-7529-061-4 (ISBN)
Disputation
2015-03-06, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2015-01-26 Skapad: 2015-01-26 Senast uppdaterad: 2017-10-17Bibliografiskt granskad

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Crafoord, SvenLöfgren, Lennart A.

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