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Infectious Disease at Gluten Introduction and Risk of Childhood Diabetes Mellitus
Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0001-6328-5494
Division of Pediatrics, Linköping University, Östergötland County Council, Linköping, Sweden; Division of Pediatrics, University Hospital, Östergötland County Council, Linköping, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Medical Epidemiology and Biostatistics, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID-id: 0000-0003-1024-5602
2014 (Engelska)Ingår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 165, nr 2, s. 326-U160Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: To investigate the risk of future diabetes mellitus type 1 (T1D) in children who suffered from infection at time of gluten introduction.

Study design: Population-based prospective study. Parents filled out a diary at home. We hereby obtained data on date of gluten introduction, breastfeeding duration, and infections in 9414 children born in the southeast of Sweden from October 1, 1997, through October 1, 1999 (the All Babies in Southeast Sweden cohort). The Cox proportional hazards model was used to investigate the risk of future T1D until February 1, 2012, among children with infection at time of gluten introduction.

Results: Forty-six children (0.5%) developed T1D and were compared with 9368 reference children from the general population. Some 10 of 46 children with later T1D had an infection at time of gluten introduction (22%) compared with 2520 reference children (27%, P = .43). Later T1D was not associated with age at end of breastfeeding, age at any infection, or age at gluten introduction. Breastfeeding at time of gluten introduction was not protective against future T1D (hazard ratio 1.2; 95% CI, 0.5-2.7). In our final model, when we adjusted for age at gluten introduction, age at infection, and breastfeeding duration, infection at time of gluten introduction did not influence the risk of future T1D (hazard ratio 0.8; 95% CI, 0.3-1.6).

Conclusion: Infection at time of gluten introduction is not a major risk factor for future T1D in nonselected children.

Ort, förlag, år, upplaga, sidor
2014. Vol. 165, nr 2, s. 326-U160
Nationell ämneskategori
Pediatrik
Forskningsämne
Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-37560DOI: 10.1016/j.jpeds.2014.04.003ISI: 000341435800025OAI: oai:DiVA.org:oru-37560DiVA, id: diva2:753156
Forskningsfinansiär
Vetenskapsrådet
Anmärkning

Funding Agencies:

Swedish Society of Medicine

Sven Jerring Foundation

Örebro Society of Medicine

Karolinska Institutet

Clas Groschinsky Foundation

Juhlin Foundation

Majblomman Foundation

Swedish Celiac Society

Juvenile Diabetes Research Foundation

Wallenberg Foundation

Swedish Medical Research Council (MRF Vetenskapsradet)

Swedish Child Diabetes Foundation (Barndiabetesfonden)

Swedish Diabetes Association

Söderberg Foundation

Novo Nordisk Foundation

Karolinska Institute Board of Postgraduate education

Örebro University Hospital

Tillgänglig från: 2014-10-07 Skapad: 2014-10-07 Senast uppdaterad: 2018-07-22Bibliografiskt granskad

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Montgomery, Scott M.Ludvigsson, Jonas F.

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