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Highly elevated serum concentrations of perfluoroalkyl substances in fishery employees from tangxun lake, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China.
Norwegian Institute for Air Research (NILU), Tromsø, Norway.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China.ORCID-id: 0000-0002-5729-1908
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2014 (engelsk)Inngår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 48, nr 7, s. 3864-3874Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Increasing production and use of per- and polyfluoroalkyl substances (PFASs) has been reported from China, and a few studies have shown there are subpopulations in China with high and increasing exposure to these chemicals. In this paper, we present a comprehensive exposure assessment of PFASs in fishery employees from Tangxun Lake, China. Exceptionally high serum concentrations of C4 to C12 PFASs were observed in fishery employees (n = 39, median perfluorooctanesulfonic acid (PFOS) 10 400 ng/mL) compared to a reference group from the same city (n = 9, median PFOS 18.7 ng/mL). On the basis of the comparison of different exposure pathways, it was concluded that contaminated fish from Tangxun Lake was the primary source of PFAS exposure to fishery employees, and there was a positive association between serum PFAS concentrations and time of employment in the fishery. PFOS isomer profiles in fishery employees showed a significantly higher proportion of linear PFOS (78.4%) compared to the background-exposed reference group (66.8%), reflecting the highly linear PFOS isomer profile (>90%) of lake fish. Median renal clearance rates (CLrenal) of C4 to C10 perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkanesulfonic acids (PFSAs) ranged from 0.020 to 16.5 mL/day/kg and 0.013 to 9.43 mL/day/kg, respectively. PFCAs with less than eight perfluoroalkyl carbons were primarily eliminated via urine, whereas other routes of excretion may have contributed to the elimination for long-chain PFCAs and PFSAs. Calculated daily PFOS exposures of fishery employees significantly exceeded tolerable daily intake limits, but clinical blood chemistry parameters were mostly within normal reference ranges. However, additional epidemiological studies are needed to address potential associations between PFAS exposure and health effects in the Tangxun Lake area.

sted, utgiver, år, opplag, sider
American Chemical Society (ACS), 2014. Vol. 48, nr 7, s. 3864-3874
Emneord [en]
Alkanesulfonic Acids; Animals; Aquatic Organisms; Carboxylic Acids; China; Environmental Monitoring; Female; Fisheries; Fluorocarbons; Humans; Kidney; Lakes; Male; Occupational Exposure; Risk Assessment
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Identifikatorer
URN: urn:nbn:se:oru:diva-38400DOI: 10.1021/es4057467ISI: 000333776100033PubMedID: 24588690Scopus ID: 2-s2.0-84897545254OAI: oai:DiVA.org:oru-38400DiVA, id: diva2:765034
Merknad

Sponsors:

National Key Basic Research Program of China  Grant no 2014CB114402 

National Natural Science Foundation of China  Grant no:s 41023005  21377145  21321004

State Environmental Protection Welfare Scientific Research Project  Grant no 201009026

Program for New Century Excellent Talents in University  Grant no NCET-11-0964 

Tilgjengelig fra: 2014-11-21 Laget: 2014-11-07 Sist oppdatert: 2018-06-11bibliografisk kontrollert

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