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Oxygen as modulator of trophoblast invasion
Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria.
Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria.ORCID-id: 0000-0003-0386-6857
Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria.
Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Graz, Austria.ORCID-id: 0000-0003-0466-1861
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2009 (Engelska)Ingår i: Journal of Anatomy, ISSN 0021-8782, E-ISSN 1469-7580, Vol. 215, nr 1, s. 14-20Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidual interstitium, extravillous trophoblasts potentially reach and transform spiral arteries into uteroplacental arteries. Spiral arterial erosion starts at about mid-first trimester, whereas flow of maternal blood into the intervillous space is continuously established only at the beginning of the second trimester. One key regulator of the number of extravillous trophoblasts is oxygen. The steep gradient in oxygen concentration within the first trimester placenta is diminished with the onset of maternal blood flow. This gradient is used by the trophoblast to generate a large number of invasive cells to adapt the arterial vasculature in the placental bed to the growing needs of the fetus. Changes in oxygen concentrations or other factors leading to alterations in the rates of proliferation and/or apoptosis of extravillous trophoblast clearly impact on the remodelling of the vessels. The respective consequences of a failure in trophoblast invasion are growth restrictions of the baby and perhaps other pregnancy complications.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2009. Vol. 215, nr 1, s. 14-20
Nyckelord [en]
extravillous trophoblast, fetal growth restriction, impaired invasion, oxygen, spiral artery
Nationell ämneskategori
Cell- och molekylärbiologi
Forskningsämne
Molekylär cellbiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-39623DOI: 10.1111/j.1469-7580.2008.01036.xISI: 000266923900003PubMedID: 19215320Scopus ID: 2-s2.0-67449167516OAI: oai:DiVA.org:oru-39623DiVA, id: diva2:771242
Tillgänglig från: 2014-12-12 Skapad: 2014-12-12 Senast uppdaterad: 2019-03-26Bibliografiskt granskad

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Gauster, MartinKönig, Julia

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