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Electrochemotherapy - possible benefits and limitations to its use in the head and neck region
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
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2015 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, no 1, p. 90-95Article in journal (Refereed) Published
Abstract [en]

Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.

Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.

Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.

Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.

Place, publisher, year, edition, pages
Informa Healthcare, 2015. Vol. 135, no 1, p. 90-95
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:oru:diva-39848DOI: 10.3109/00016489.2014.947655ISI: 000346275600013PubMedID: 25496181Scopus ID: 2-s2.0-84918592776OAI: oai:DiVA.org:oru-39848DiVA, id: diva2:772319
Note

Funding agency: Genetronics Inc., San Diego, CA, USA

Available from: 2014-12-16 Created: 2014-12-16 Last updated: 2018-06-26Bibliographically approved
In thesis
1. Curative electrochemotherapy in the head and neck area
Open this publication in new window or tab >>Curative electrochemotherapy in the head and neck area
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. p. 94
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 117
National Category
Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:oru:diva-42215 (URN)978-91-7529-061-4 (ISBN)
Public defence
2015-03-06, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (English)
Opponent
Supervisors
Available from: 2015-01-26 Created: 2015-01-26 Last updated: 2017-10-17Bibliographically approved

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Landström, Fredrikvon Beckerath, MathiasLöfgren, LennartMöller, Claes

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