oru.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress
Örebro universitet, Institutionen för hälsovetenskap och medicin. (NGBI)ORCID-id: 0000-0003-4713-1772
Örebro universitet, Institutionen för hälsovetenskap och medicin. (NGBI)ORCID-id: 0000-0003-3383-9219
Department of Microbiology, Wageningen University, Wageningen,The Netherlands.
Department of Microbiology, Wageningen University, Wageningen,The Netherlands.
Vise andre og tillknytning
2015 (engelsk)Inngår i: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 41, nr 4, s. 342-351Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: A subset of irritable bowel syndrome (IBS) patients, denoted post-infectious IBS (PI-IBS), develop symptoms after an enteric infection. Bacterial dysbiosis and mucosal inflammation have been proposed to be involved in the pathophysiology of this entity.

Aim: To characterise the mucosal and faecal microbiota in PI-IBS, general IBS and healthy controls, and to investigate associations between the microbiota and the mucosal immune system.

Methods: Mucosal biopsies and faeces were collected from 13 PI-IBS patients, 19 general IBS patients and 16 healthy controls. Global bacterial composition was determined by generating 16S rRNA amplicons that were examined by phylogenetic microarray hybridisation, principal component and redundancy analysis. We correlated previously reported lymphocyte proportions with the microbiota.

Results: Faecal microbiota composition of PI-IBS patients differed significantly from both general IBS patients and healthy controls (P < 0.02). Both mucosal (P < 0.01) and faecal (P = 0.05) microbial diversity were reduced in PI-IBS compared to healthy controls. In the intraepithelial lymphocytes the previously published proportion of CD8+ CD45RA+ was negatively correlated with mucosal microbial diversity (P < 0.005). The previously published number of lamina propria lymphocytes was negatively correlated with mucosal microbial diversity (P < 0.05). Faecal microbial diversity was significantly negatively correlated with the Hospital Anxiety and Depression scale (P < 0.05).

Conclusions: We present data that distinguishes the intestinal microbiota of PI-IBS patients from that of both general IBS patients and HC. The microbial composition is significantly associated with the HADs score and alterations in lymphocyte subsets proportions.

sted, utgiver, år, opplag, sider
Hoboken, USA: Wiley-Blackwell, 2015. Vol. 41, nr 4, s. 342-351
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-39955DOI: 10.1111/apt.13055ISI: 000348731200002PubMedID: 25521822Scopus ID: 2-s2.0-84921438829OAI: oai:DiVA.org:oru-39955DiVA, id: diva2:774083
Merknad

Funding Agencies:

Medical Faculty, Orebro University

Spinoza award of the Netherlands Organization for Scientific Research

Gravity grant (SIAM) of the Netherlands Organization for Scientific Research

Tilgjengelig fra: 2014-12-22 Laget: 2014-12-22 Sist oppdatert: 2018-01-11bibliografisk kontrollert
Inngår i avhandling
1. Microbe-host interactions in post-infectious irritable bowel syndrome
Åpne denne publikasjonen i ny fane eller vindu >>Microbe-host interactions in post-infectious irritable bowel syndrome
2015 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2015. s. 97
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 114
Emneord
IBS, PI-IBS, Intestinal, Mucosa, Lymphocyte, Microbiota, Bacteria, Cytokine, Addaptive immune response, IL-13
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
urn:nbn:se:oru:diva-41109 (URN)978-91-7529-057-7 (ISBN)
Disputas
2015-02-27, Prismahuset, Hörsal 2, Örebro universitet, Fakultetsgatan 1, Örebro, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2015-01-13 Laget: 2015-01-13 Sist oppdatert: 2017-10-17bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Sundin, JohannaRangel, IgnacioHultgren-Hörnquist, ElisabethBrummer, Robert-Jan

Søk i DiVA

Av forfatter/redaktør
Sundin, JohannaRangel, IgnacioHultgren-Hörnquist, ElisabethBrummer, Robert-Jan
Av organisasjonen
I samme tidsskrift
Alimentary Pharmacology and Therapeutics

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 696 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf