oru.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Functional correlations of pathogenesis-driven gene expression signatures in tuberculosis
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
Medical Research Council Laboratories, Banjul, The Gambia.
Leibniz Institute for Farm Animal Biology Genetics and Biometry, Dummersdorf, Germany.ORCID-id: 0000-0002-7173-5579
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
Vise andre og tillknytning
2011 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 6, nr 10, artikkel-id e26938Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Tuberculosis remains a major health threat and its control depends on improved measures of prevention, diagnosis and treatment. Biosignatures can play a significant role in the development of novel intervention measures against TB and blood transcriptional profiling is increasingly exploited for their rational design. Such profiles also reveal fundamental biological mechanisms associated with the pathology of the disease. We have compared whole blood gene expression in TB patients, as well as in healthy infected and uninfected individuals in a cohort in The Gambia, West Africa and validated previously identified signatures showing high similarities of expression profiles among different cohorts. In this study, we applied a unique combination of classical gene expression analysis with pathway and functional association analysis integrated with intra-individual expression correlations. These analyses were employed for identification of new disease-associated gene signatures, identifying a network of Fc gamma receptor 1 signaling with correlating transcriptional activity as hallmark of gene expression in TB. Remarkable similarities to characteristic signatures in the autoimmune disease systemic lupus erythematosus (SLE) were observed. Functional gene clusters of immunoregulatory interactions involving the JAK-STAT pathway; sensing of microbial patterns by Toll-like receptors and IFN-signaling provide detailed insights into the dysregulation of critical immune processes in TB, involving active expression of both pro-inflammatory and immunoregulatory systems. We conclude that transcriptomics (i) provides a robust system for identification and validation of biosignatures for TB and (ii) application of integrated analysis tools yields novel insights into functional networks underlying TB pathogenesis.

sted, utgiver, år, opplag, sider
San Fransisco, USA: Public Library Science , 2011. Vol. 6, nr 10, artikkel-id e26938
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-40620DOI: 10.1371/journal.pone.0026938PubMedID: 22046420Scopus ID: 2-s2.0-80055042377OAI: oai:DiVA.org:oru-40620DiVA, id: diva2:777957
Tilgjengelig fra: 2015-01-09 Laget: 2015-01-09 Sist oppdatert: 2018-05-06bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Repsilber, Dirk

Søk i DiVA

Av forfatter/redaktør
Repsilber, Dirk
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 217 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf