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Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Centre for Rehabilitation Research, Region Örebro County, Örebro, Sweden.ORCID-id: 0000-0002-7468-1633
Department of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK.
Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK.
Department of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK.
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2014 (Engelska)Ingår i: Autoimmune Diseases, ISSN 2090-0422, E-ISSN 2090-0430, artikel-id 237107Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objectives: We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease (CD). Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction. The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP.

Materials and Methods: Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA.

Results: Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls. The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls. There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin.

Conclusions: An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity.

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Hindawi Publishing Corporation, 2014. artikel-id 237107
Nationell ämneskategori
Pediatrik
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URN: urn:nbn:se:oru:diva-42602DOI: 10.1155/2014/237107PubMedID: 24804082Scopus ID: 2-s2.0-84899518843OAI: oai:DiVA.org:oru-42602DiVA, id: diva2:787972
Tillgänglig från: 2015-02-12 Skapad: 2015-02-12 Senast uppdaterad: 2018-06-15Bibliografiskt granskad

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Stenberg, Reidun

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