Pattern of microbial translocation in patients living with HIV-1 from Vietnam, Ethiopia and SwedenShow others and affiliations
2014 (English)In: Journal of the International AIDS Society, E-ISSN 1758-2652, Vol. 17, p. 18841-Article in journal (Refereed) Published
Abstract [en]
INTRODUCTION: The role of microbial translocation (MT) in HIV patients living with HIV from low- and middle-income countries (LMICs) is not fully known. The aim of this study is to investigate and compare the patterns of MT in patients from Vietnam, Ethiopia and Sweden.
METHODS: Cross-sectional samples were obtained from treatment-naïve patients living with HIV-1 and healthy controls from Vietnam (n=83; n=46), Ethiopia (n=9492; n=50) and Sweden (n=51; n=19). Longitudinal samples were obtained from a subset of the Vietnamese (n=24) in whom antiretroviral therapy (ART) and tuberculostatics were given. Plasma lipopolysaccharide (LPS), sCD14 and anti-flagellin IgG were determined by the endpoint chromogenic Limulus Amebocyte Assay and enzyme-linked immunosorbent assay.
RESULTS: All three biomarkers were significantly increased in patients living with HIV-1 from all countries as compared to controls. No differences were found between males and females. Vietnamese and Ethiopian patients had significantly higher levels of anti-flagellin IgG and LPS, as compared to Swedes. ART reduced these levels for the Vietnamese. Vietnamese patients given tuberculostatics at initiation of ART had significantly lower levels of anti-flagellin IgG and higher sCD14. The biomarkers were lower in Vietnamese who did not develop opportunistic infection.
CONCLUSIONS: Higher MT is common in patients living with HIV compared to healthy individuals, and in patients from LMICs compared to patients from a high-income country. Treatment with tuberculostatics decreased MT while higher levels of MT are associated with a poorer clinical outcome.
Place, publisher, year, edition, pages
2014. Vol. 17, p. 18841-
Keywords [en]
HIV in Ethiopia; HIV in Sweden; HIV in Vietnam; Immune activation; LPS; Microbial translocation; sCD14; Treatment-naïve patients living with HIV
National Category
Infectious Medicine Immunology in the medical area
Research subject
Infectious Diseases; Immunology
Identifiers
URN: urn:nbn:se:oru:diva-41998DOI: 10.7448/IAS.17.1.18841ISI: 000330631300001PubMedID: 24461466Scopus ID: 2-s2.0-84896819433OAI: oai:DiVA.org:oru-41998DiVA, id: diva2:792886
Funder
Sida - Swedish International Development Cooperation AgencySwedish Research Council, 521-2012-3476
Note
Funding Agencies:
European and Developing Countries Clinical Trial Partnership
Swedish Civil Contingencies Agency SWE-2009-151
2015-03-052015-01-162023-11-14Bibliographically approved