To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Pattern of microbial translocation in patients living with HIV-1 from Vietnam, Ethiopia and Sweden
Division of Clinical Microbiology, Department of Laboratory Medicine F68, Karolinska University Hospital, Stockholm, Sweden.ORCID iD: 0000-0003-0902-508X
Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Infectious Diseases Department, Bach Mai Hospital, Hanoi, Viet Nam .
Show others and affiliations
2014 (English)In: Journal of the International AIDS Society, E-ISSN 1758-2652, Vol. 17, p. 18841-Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: The role of microbial translocation (MT) in HIV patients living with HIV from low- and middle-income countries (LMICs) is not fully known. The aim of this study is to investigate and compare the patterns of MT in patients from Vietnam, Ethiopia and Sweden.

METHODS: Cross-sectional samples were obtained from treatment-naïve patients living with HIV-1 and healthy controls from Vietnam (n=83; n=46), Ethiopia (n=9492; n=50) and Sweden (n=51; n=19). Longitudinal samples were obtained from a subset of the Vietnamese (n=24) in whom antiretroviral therapy (ART) and tuberculostatics were given. Plasma lipopolysaccharide (LPS), sCD14 and anti-flagellin IgG were determined by the endpoint chromogenic Limulus Amebocyte Assay and enzyme-linked immunosorbent assay.

RESULTS: All three biomarkers were significantly increased in patients living with HIV-1 from all countries as compared to controls. No differences were found between males and females. Vietnamese and Ethiopian patients had significantly higher levels of anti-flagellin IgG and LPS, as compared to Swedes. ART reduced these levels for the Vietnamese. Vietnamese patients given tuberculostatics at initiation of ART had significantly lower levels of anti-flagellin IgG and higher sCD14. The biomarkers were lower in Vietnamese who did not develop opportunistic infection.

CONCLUSIONS: Higher MT is common in patients living with HIV compared to healthy individuals, and in patients from LMICs compared to patients from a high-income country. Treatment with tuberculostatics decreased MT while higher levels of MT are associated with a poorer clinical outcome.

Place, publisher, year, edition, pages
2014. Vol. 17, p. 18841-
Keywords [en]
HIV in Ethiopia; HIV in Sweden; HIV in Vietnam; Immune activation; LPS; Microbial translocation; sCD14; Treatment-naïve patients living with HIV
National Category
Infectious Medicine Immunology in the medical area
Research subject
Infectious Diseases; Immunology
Identifiers
URN: urn:nbn:se:oru:diva-41998DOI: 10.7448/IAS.17.1.18841ISI: 000330631300001PubMedID: 24461466Scopus ID: 2-s2.0-84896819433OAI: oai:DiVA.org:oru-41998DiVA, id: diva2:792886
Funder
Sida - Swedish International Development Cooperation AgencySwedish Research Council, 521-2012-3476
Note

Funding Agencies:

European and Developing Countries Clinical Trial Partnership

Swedish Civil Contingencies Agency SWE-2009-151

Available from: 2015-03-05 Created: 2015-01-16 Last updated: 2023-11-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Abdurahman, Samir

Search in DiVA

By author/editor
Abdurahman, Samir
In the same journal
Journal of the International AIDS Society
Infectious MedicineImmunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1308 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf