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Autism spectrum disorder and low vitamin D at birth: a sibling control study
Gillberg Neuropsychiat Ctr, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden; Res & Dev Ctr, Skaraborgs Hosp, Skövde, Sweden.
Dept Clin Neurosci, Karolinska Inst, Stockholm, Sweden.ORCID iD: 0000-0002-3587-6075
Dept Psychol, Univ Stockholm, Stockholm, Sweden.
Gillberg Neuropsychiat Ctr, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden.
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2015 (English)In: Molecular Autism, ISSN 2040-2392, ISSN 2040-2392, Vol. 6, article id 3Article in journal (Refereed) Published
Abstract [en]

Background: Insufficient vitamin D activity has attracted increasing interest as a possible underlying risk factor in disorders of the central nervous system, including autism.

Methods: In this study, 25-hydroxyvitamin D (25(OH) D) was analysed in 58 Sweden-born sibling pairs, in which one child had autism spectrum disorder (ASD) and the other did not. The study group consisted of two representative samples; 47 Gothenburg sibling pairs with mixed ethnicities and 11 Stockholm sibling pairs with Somali background. 25(OH) D levels were analysed in the stored dried blood spots taken in the neonatal period for metabolic screening.

Results: The collapsed group of children with ASD had significantly lower vitamin D levels (M = 24.0 nM, SD = 19.6) as compared with their siblings (M = 31.9 nM, SD = 27.7), according to a paired samples t-test (P = 0.013). The difference was-most likely-not only accounted for by a difference in season of birth between ASD and non-ASD siblings since the mean 25(OH)D levels differed with similar effect size between the sibling pairs born during winter and summer, respectively. All children with African/Middle East background, both the children with ASD and their non-ASD siblings, had vitamin D deficiency.

Conclusions: The findings suggest that low prenatal vitamin D may act as a risk factor for ASD, however, there is a need for replication with larger samples. Future research should study whether or not adequate supplementation of vitamin D to pregnant women might lower the risk for ASD in the offspring.

Place, publisher, year, edition, pages
2015. Vol. 6, article id 3
Keywords [en]
Autism spectrum disorder, Vitamin D, 25-hydroxyvitamin D, Neonatal, Dried blood spots
National Category
Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-44116DOI: 10.1186/2040-2392-6-3ISI: 000350599000002OAI: oai:DiVA.org:oru-44116DiVA, id: diva2:801071
Funder
Swedish Research Council, 523-2011-3646
Note

Funding Agency:

'Föreningen Mjölkdroppen' in Stockholm

Available from: 2015-04-08 Created: 2015-04-08 Last updated: 2020-01-23Bibliographically approved

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Bejerot, SusanneHumble, Mats B.

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