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Epidemiologiskt påvisade samband mellan Parkinsons sjukdom och faktorer i arbetsmiljön
Örebro universitet, Institutionen för läkarutbildning.ORCID-id: 0000-0002-4192-8273
2014 (svensk)Inngår i: Systematiska kunskapsöversikter: 6. Epidemiologiskt påvisade samband mellan Parkinsons sjukdom och faktorer i arbetsmiljön / [ed] Lars-Gunnar Gunnarsson och Lennart Bodin, Göteborg: Göteborgs universitet , 2014, s. 11-79Kapittel i bok, del av antologi (Fagfellevurdert)
Abstract [en]

Epidemiological evidence on associations between work environment and Parkinson’s disease.

Lars-Gunnar Gunnarsson, assistant professor at School of Medicine, Örebro University, Sweden and

Lennart Bodin, professor emeritus, Department of Statistics, Örebro University, Sweden and senior researcher at Institute of Environmental Medicine, Karolinska Institute, Sweden.

In this systematic literature review we identified 93 original publications on associations between work and Parkinson’s disease (PD). GRADE guidelines were used to secure high scientific quality and reliable guidelines were applied to classify the papers. Forty-nine papers fulfilled high quality standards while 44 were methodologically deficient and thus were excluded from our meta-analyses.

Twenty five publications concerned work exposure to pesticides. The weighted relative risk (RR) estimate was 1.72 (95% confidence interval 1.46-2.04). A funnel plot and tests indicated that some publication bias concerning smaller studies might have been present. The risk estimate was not influenced by study design (case-control, cohort or cross section study) or gender. Higher estimates were found when there was a hereditary taint or onset below age 60.

In 15 publications exposure to electromagnetic fields was considered and there was no indication of risk, RR 1.07 (95% confidence interval 0.98-1.18).

Meta-analyses of ten studies on exposure for metals showed a statistically diminished risk estimate, RR 0.85 (95% confidence interval 0.82-0.89). A proposed explanation to this seemingly beneficial effect is hormesis meaning that exposures of a low-moderate dosage of toxic agents can induce neuroprotective mechanisms.

 

sted, utgiver, år, opplag, sider
Göteborg: Göteborgs universitet , 2014. s. 11-79
Serie
Arbete och Hälsa, Vetenskaplig skriftserie, ISSN 0346-7821 ; 48(1)
Emneord [sv]
Metaanalys
HSV kategori
Forskningsprogram
Epidemiologi; Medicin; Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-44192ISBN: 978-91-85971-50-3 (tryckt)OAI: oai:DiVA.org:oru-44192DiVA, id: diva2:801384
Forskningsfinansiär
AFA InsuranceTilgjengelig fra: 2015-04-09 Laget: 2015-04-09 Sist oppdatert: 2017-10-17bibliografisk kontrollert

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