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Placental gene expression of inflammatory markers and growth factors: a case control study of obese and normal weight women
Örebro universitet, Institutionen för hälsovetenskap och medicin. Dept Obstet & Gynaecol, Örebro Univ Hosp, Örebro, Sweden.
Örebro universitet, Institutionen för läkarutbildning. Dept Paediat, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för läkarutbildning. Dept Obstet & Gynaecol, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Dept Obstet & Gynaecol, Örebro University Hospital, Örebro, Sweden.
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2015 (Engelska)Ingår i: Journal of Perinatal Medicine, ISSN 0300-5577, E-ISSN 1619-3997, Vol. 43, nr 2, s. 159-164Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To survey the placental gene expression of inflammatory markers and growth factors in non-smoking obese women with an uncomplicated pregnancy without associated morbidity and delivery at term compared with normal weight women.

Methods: Placental tissue samples from 32 obese women (body mass index, BMI >= 35.0 kg/m(2)) were compared with samples from 94 normal weight women (BMI 18.5-25.0 kg/m(2)) matched for age (+/- 1 year), gestational age (+/- 3 days), parity and mode of delivery. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to analyse toll receptor-2 and -4, interleukin-6 and -8, tumour necrosis factor-alpha, leptin, adiponectin, insulin-like growth factor-1 and -2, hepatocyte growth factor, hepatocyte growth factor receptor and insulin receptor.

Results: There was no significant difference in gene expression in placental tissue samples from obese and normal weight women.

Conclusion: We found no difference in the occurrence of inflammatory marker and growth factor mRNA levels in placental tissue samples from a large group of obese women without associated morbidity and with healthy infants compared to a closely matched control group of healthy normal weight women. Compared with the previous studies, this anomalous finding may be explained by the absence of associated morbidity in the obese women in our study.

Ort, förlag, år, upplaga, sidor
Walter de Gruyter, 2015. Vol. 43, nr 2, s. 159-164
Nyckelord [en]
Obesity, pregnancy
Nationell ämneskategori
Reproduktionsmedicin och gynekologi Pediatrik
Forskningsämne
Obstetrik och gynekologi; Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-44240DOI: 10.1515/jpm-2013-0343ISI: 000350338000005PubMedID: 25014513Scopus ID: 2-s2.0-84945571575OAI: oai:DiVA.org:oru-44240DiVA, id: diva2:804982
Anmärkning

Funding Agency:

Foundation for Medical Research, Orebro University Hospital

Tillgänglig från: 2015-04-14 Skapad: 2015-04-14 Senast uppdaterad: 2023-12-08Bibliografiskt granskad
Ingår i avhandling
1. Gene expression of inflammatory markers and growth factors in placenta in relation to maternal obesity and foetal and postnatal growth
Öppna denna publikation i ny flik eller fönster >>Gene expression of inflammatory markers and growth factors in placenta in relation to maternal obesity and foetal and postnatal growth
2020 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Maternal obesity is a growing health problem, that contributes to obstetrical complications in pregnancy, as well as neonatal morbidity and mortality. The placenta serves for gas and nutrient exchange between the mother and the foetus, and obesity may influence and modify placental growth and function. The aims of this thesis were to investigate associations between maternal obesity without associated morbidity and gene expression of inflammatory markers and growth factors in the placenta, as well as offspring birth weight and postnatal growth. 

Study I and III were designed as matched case-control studies including 32 obese women with an early pregnancy body mass index (BMI) ≥ 35.0 kg/m2, study II was an experimental study examining twelve placentas of normal weight women, and study IV was a cohort study including 109 obese women with a BMI ≥ 34.5 kg/m2. In studies I-IV analyses of gene expression were performed and in study III additionally cord blood concentrations were determined. 

No difference was found in the occurrence of placental gene expression of inflammatory markers or growth factors between obese and normal weight women, nor did the sampling site in placentas of normal weight women influence gene expression of these markers, except for leptin gene (LEP) and insulin receptor gene (INSR) expression. Ghrelin gene (GHRL) and LEP expression, as well as cord blood ghrelin and adiponectin levels, was not altered in maternal obesity, and a negatively U-shaped relationship between LEP expression and infant birth weight (BW) z-scores was observed in the placentas of obese women.

In conclusion, no statistically significant difference in gene expressions of inflammatory markers and growth factors in the placenta between severely obese and normal weight women was found. These results are in contrast with earlier studies and could be due to the fact that we examined mainly healthy obese women. The correlations we found between gene expression of leptin in the placenta and the birth weight of the infants warrants further studies.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University, 2020. s. 93
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 221
Nyckelord
obesity, pregnancy, placenta, gene expression, cytokines
Nationell ämneskategori
Annan medicinsk grundvetenskap
Identifikatorer
urn:nbn:se:oru:diva-80923 (URN)978-91-7529-354-7 (ISBN)
Disputation
2020-10-16, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2020-03-31 Skapad: 2020-03-31 Senast uppdaterad: 2020-09-21Bibliografiskt granskad

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Allbrand, MarianneBjörkqvist, MariaNilsson, KerstinÖstlund, IngridÅman, Jan

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Allbrand, MarianneBjörkqvist, MariaNilsson, KerstinÖstlund, IngridÅman, Jan
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Institutionen för hälsovetenskap och medicinInstitutionen för läkarutbildningRegion Örebro länÖrebro universitet
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Journal of Perinatal Medicine
Reproduktionsmedicin och gynekologiPediatrik

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