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Parental cancer diagnosis and child mortality: a population-based cohort study in Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
University of Maryland School of Medicine, Baltimore MD, USA.
Vise andre og tillknytning
2015 (engelsk)Inngår i: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 39, nr 1, s. 79-85Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: Cancer diagnosis is known to induce severe psychological stress for the diagnosed patients; however, how it affects the next-of-kin is less well documented. This study aimed to assess the impact of parental cancer on the risk of childhood death.

Methods: A population-based cohort study was conducted using the Swedish national registries, including 2,871,242 children followed during the period of 1991-2009. Parental cancer diagnosis was defined as a time-varying exposure. We used Cox proportional hazards regression to calculate the hazard ratio (HR) and its corresponding 95% confidence interval (CI) as an estimate of the association between parental cancer and childhood mortality. We adjusted for attained age, sex, gestational age, mode of delivery and birth weight of the child, maternal age at child's birth, as well as educational level and socioeconomic classification of the parents in the analyses.

Results: Among 113,555 children with parental cancer, 127 deaths occurred during 561,198 person-years of follow-up. A parental cancer diagnosis was associated with an increased rate of death among children at the age of 1-18 (HR for all-cause death: 1.39; 95% CI: 1.16-1.66). For young children (aged 112), an increased rate was only noted for death due to cancer (HR: 2.06; 95% CI: 1.13-3.75) after parental cancer diagnosis. Among adolescents (aged 13-18), an increased rate was noted for all-cause death (HR: 1.52; 95% CI: 1.25-1.86), and for both non-cancer-related (HR: 1.43; 95% CI: 1.14-1.79) and cancer-related (HR: 2.07; 95% CI: 1.33-3.24) death in the exposed children.

Conclusion: Children have an increased rate of death if they have a parent diagnosed with cancer as compared to children without such experience; this association appears to be slightly stronger among adolescents. (C) 2014 Elsevier Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
American Diabetes Association , 2015. Vol. 39, nr 1, s. 79-85
Emneord [en]
Cancer; Child of impaired parents; Cohort study; Death
HSV kategori
Forskningsprogram
Onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-44349DOI: 10.1016/j.canep.2014.11.011ISI: 000351232800012PubMedID: 25548077Scopus ID: 2-s2.0-84925069911OAI: oai:DiVA.org:oru-44349DiVA, id: diva2:806369
Forskningsfinansiär
Swedish Research Council, SIMSAM 80748301 340-2013-5867Swedish Society for Medical Research (SSMF)
Merknad

Funding Agencies:

Swedish Research Council for Health, Working Life and Welfare 2012-0498

China Scholarship Council 201206100002

Karolinska Institutet

Tilgjengelig fra: 2015-04-20 Laget: 2015-04-20 Sist oppdatert: 2018-06-29bibliografisk kontrollert

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