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Association between serotype-specific antibody response and serotype characteristics in patients with pneumococcal pneumonia, with special reference to degree of encapsulation and invasive potential
Örebro University Hospital.ORCID iD: 0000-0002-8730-6955
Statens Serum Institut, Copenhagen, Denmark.
Statens Serum Institut, Copenhagen, Denmark.
Uppsala University, Uppsala, Sweden.
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2014 (English)In: Clinical and Vaccine Immunology, ISSN 1556-6811, E-ISSN 1556-679X, Vol. 21, no 11, p. 1541-1549Article in journal (Refereed) Published
Abstract [en]

We studied the immunoglobulin (Ig) response to causative serotype-specific capsular polysaccharides in adult pneumococcal pneumonia patients. The serotypes were grouped according to their degree of encapsulation and invasive potential. Seventy patients with pneumococcal pneumonia, 20 of whom were bacteremic, were prospectively studied. All pneumococcal isolates from the patients were serotyped, and the Ig titers to the homologous serotype were determined in acute- and convalescent-phase sera using a serotype-specific enzyme-linked immunosorbent assay. The Ig titers were lower in bacteremic cases than in nonbacteremic cases (P < 0.042). The Ig titer ratio (convalescent/acute titer) was ≥2 in 33 patients, 1 to 1.99 in 20 patients, and <1 in 17 patients. Patients ≥65 years old had a lower median Ig titer ratio than did younger patients (P < 0.031). The patients with serotypes with a thin capsule (1, 4, 7F, 9N, 9V, and 14) and medium/high invasive potential (1, 4, 7F, 9N, 9V, 14, and 18C) had higher Ig titer ratios than did patients with serotypes with a thick capsule (3, 6B, 11A, 18C, 19A, 19F, and 23F) and low invasive potential (3, 6B, 19A, 19F, and 23F) (P < 0.05 for both comparisons after adjustment for age). Ig titer ratios of <1 were predominantly noted in patients with serotypes with a thick capsule. In 8 patients with pneumococcal DNA detected in plasma, the three patients with the highest DNA load had the lowest Ig titer ratios. In conclusion, a high antibody response was associated with serotypes with a thin capsule and medium/high invasive potential, although a low antibody response was associated with serotypes with a thick capsule and a high pneumococcal plasma load.

Place, publisher, year, edition, pages
American Society for Microbiology , 2014. Vol. 21, no 11, p. 1541-1549
National Category
Infectious Medicine Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-44373DOI: 10.1128/CVI.00259-14ISI: 000344651200011PubMedID: 25230937Scopus ID: 2-s2.0-84914697787OAI: oai:DiVA.org:oru-44373DiVA, id: diva2:806947
Note

Funding Agency: Research Committee of Orebro County Council OLL-137011

Available from: 2015-04-22 Created: 2015-04-20 Last updated: 2019-04-24Bibliographically approved
In thesis
1. Detection of polysaccharides and polysaccharide antibodies in pneumococcal pneumonia
Open this publication in new window or tab >>Detection of polysaccharides and polysaccharide antibodies in pneumococcal pneumonia
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. p. 93
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 121
Keywords
Streptococcus pneumoniae, pneumococcus, pneumonia, cellwall polysaccharide, capsular polysaccharide, antibody urinary antigen, nasopharyngeal aspirate, antibody, immunoglobulin, adult
National Category
Microbiology in the medical area
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-43010 (URN)978-91-7529-073-7 (ISBN)
Public defence
2015-05-08, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 09:00 (Swedish)
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Supervisors
Note

Funding: Research Committee of Region Orebro County Council

Available from: 2015-02-27 Created: 2015-02-27 Last updated: 2019-04-24Bibliographically approved

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Athlin, Simon

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