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Hospitalization for osteoarthritis and prostate cancer specific mortality among Swedish men with prostate cancer
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 34, nr 5, s. 644-7Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To examine the potential role of nonsteroidal anti-inflammatory drugs (NSAIDs) use on prostate cancer (PCa) specific mortality.

Methods: We studied the association between hospitalization for osteoarthritis prior to PCa diagnosis, as a surrogate for heavy use of NSAIDs, and PCa specific mortality in a large population of PCa patients in Sweden in 1980-2004.

Results: Hospitalization for osteoarthritis before PCa diagnosis was associated to a lower PCa specific mortality (hazard ratio [HR], 0.92; 95% confidence interval [CI], 0.88-0.96), but not to the risk of death from other causes (HR, 1.03; 95% CI, 0.99-1.08). The association was stronger among younger patients and patients diagnosed in earlier calendar years.

Conclusions: Our data demonstrate a modestly decreased PCa specific mortality among PCa patients with hospitalization for osteoarthritis prior to PCa diagnosis, compared to those without such experience. This finding lends support to the hypothesis that NSAIDs use may influence PCa progression.

sted, utgiver, år, opplag, sider
Oxon, United Kingdom: Elsevier, 2010. Vol. 34, nr 5, s. 644-7
Emneord [en]
NSAIDs, osteoarthritis, prostate cancer specific mortality
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-41450DOI: 10.1016/j.canep.2010.05.011ISI: 000283974700021PubMedID: 20561833Scopus ID: 2-s2.0-77957240704OAI: oai:DiVA.org:oru-41450DiVA, id: diva2:811702
Tilgjengelig fra: 2015-05-12 Laget: 2015-01-14 Sist oppdatert: 2018-04-25bibliografisk kontrollert

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