oru.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Accuracy and reproducibility of a quantitative magnetic resonance imaging method for concurrent measurements of tissue relaxation times and proton density
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Örebro universitet, Institutionen för läkarutbildning.
Örebro universitet, Institutionen för läkarutbildning.
Department of Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID-id: 0000-0002-8351-3367
2015 (Engelska)Ingår i: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 33, nr 5, s. 584-591Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: To evaluate the accuracy and reproducibility of a quantitative magnetic resonance (qMR) imaging method (QRAPMASTER) for simultaneous measurements of T1 and T2 relaxation times, and proton density (PD).

Materials and Methods: Measurements of T1, T2, and PD with qMR were performed using phantoms with different relaxation times and concentrations of heavy water. Healthy volunteers were examined with different head coils. Regional measurements were performed in normal-appearing white and gray matter from the healthy control subjects, and in multiple sclerosis (MS) patients.

Results: In phantom measurements, QRAPMASTER slightly underestimated T1, and T2 variations between repeated measurements were modest. PD was generally overestimated. The overall relative difference was 1.2 5.3% (T1), 6.6 1.9% (12), and 0.7 5.1% (PD). In healthy volunteers, there were no statistically significant differences of T1, T2 or PD using different head coils. Values of T1, T2, and PD obtained in healthy controls and MS patients were within reference ranges. However, significant differences were found in normal-appearing gray and white matter.

Conclusion: QRAPMASTER can be considered a sufficiently accurate and reproducible method for use in clinical practice. Neuropathology in normal-appearing brain tissue may be revealed using this MR method, with putative implications for quantification of tissue damage in neurological diseases. (C) 2015 Elsevier Inc. All rights reserved.

Ort, förlag, år, upplaga, sidor
Elsevier, 2015. Vol. 33, nr 5, s. 584-591
Nyckelord [en]
Quantitative MRI, Synthetic MRI, T1 mapping, T2 mapping, PD mapping, Multiple sclerosis
Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
Radiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-44898DOI: 10.1016/j.mri.2015.02.013ISI: 000354831500011PubMedID: 25708264OAI: oai:DiVA.org:oru-44898DiVA, id: diva2:821500
Tillgänglig från: 2015-06-15 Skapad: 2015-06-15 Senast uppdaterad: 2019-03-22Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Krauss, WolfgangGunnarsson, MartinAndersson, TorbjornThunberg, Per

Sök vidare i DiVA

Av författaren/redaktören
Krauss, WolfgangGunnarsson, MartinAndersson, TorbjornThunberg, Per
Av organisationen
Institutionen för hälsovetenskap och medicinInstitutionen för läkarutbildning
I samma tidskrift
Magnetic Resonance Imaging
Radiologi och bildbehandling

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 447 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf