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Characteristics in childhood and adolescence associated with future multiple sclerosis risk in men: cohort study
Örebro universitet, Institutionen för läkarutbildning.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Clinical Epidemiology Unit and Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden; Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran .
Örebro universitet, Institutionen för hälsovetenskap och medicin.ORCID-id: 0000-0002-9760-3785
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2015 (engelsk)Inngår i: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 22, nr 7, s. 1131-1137Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background and purpose: Associations with multiple sclerosis (MS) of living conditions in childhood and characteristics in adolescence including physical fitness, cognitive function and psychological stress resilience were investigated.

Methods: A cohort of male Swedish residents born 1952-1956 who were included in the Swedish Military Conscription Register was used to create a nested case-control study comprising 628 MS cases and 6187 controls matched on birth year, county of residence and vital status at time of diagnosis. Conscription examination records were linked with other national register data. Conditional logistic regression was used to evaluate associations with MS subsequent to the conscription examination.

Results and conclusions: Men with MS were less likely to be from more crowded households in childhood (>two persons per room) with an adjusted odds ratio of 0.67 (95% confidence interval 0.51-0.86, P=0.023). They had lower physical working capacity in adolescence with adjusted odds ratio of 0.94 (95% confidence interval 0.89-0.99, P=0.026). Cognitive function and stress resilience scores displayed no significant differences between cases and controls. Parental occupation in childhood and body mass index in adolescence were not associated with future MS risk. The inverse association of MS risk with higher levels of household crowding may reflect environmental factors such as the pattern of exposure to microorganisms. Lower physical fitness in men at MS risk may indicate a protective effect of exercise or could be due to prodromal disease activity, although there was no association with cognitive function. Poor psychological stress resilience (and thus risk of chronic stress arousal) was not associated with MS.

sted, utgiver, år, opplag, sider
2015. Vol. 22, nr 7, s. 1131-1137
Emneord [en]
cognitive function, cohort, multiple sclerosis, physical fitness, stress
HSV kategori
Forskningsprogram
Neurologi
Identifikatorer
URN: urn:nbn:se:oru:diva-45290DOI: 10.1111/ene.12718ISI: 000356090800016PubMedID: 25919640Scopus ID: 2-s2.0-84930764895OAI: oai:DiVA.org:oru-45290DiVA, id: diva2:842859
Merknad

Funding Agencies:

UK Economic and Social Research Council RES-596-28-0001 ES/J019119/1

Örebro University

Tilgjengelig fra: 2015-07-23 Laget: 2015-07-20 Sist oppdatert: 2018-07-20bibliografisk kontrollert

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Gunnarsson, MartinUdumyan, RuzanNilsagård, YlvaMontgomery, Scott

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