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Electrochemotherapy: Evidence for Cell-type Selectivity In Vitro
Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Region Örebro län. Clinical Research Center, Örebro University Hospital, Örebro, Sweden.
School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Clinical Research Center, Örebro University Hospital, Örebro, Sweden.
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2015 (Engelska)Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 35, nr 11, s. 5813-5820Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect and an anti-vascular effect. The aim of the present study was to investigate a possible selective effect of ECT on the survival of fibroblasts, endothelial cells (HUVEC) and two squamous cell carcinoma cell lines (CAL-27 and SCC-4).

Materials and Methods: Cells were electroporated using two bleomycin concentrations. The survival rate was assessed 1, 2, 3 and 4 days after treatment, by two different assays.

Results: The survival rate of the fibroblasts was statistically significantly higher than the other cell lines at day 4. The HUVEC survival rate was statistically significantly lower than the other cell types at day 1 after electroporation-alone.

Conclusion: A selective survival effect after ECT was observed in vitro, supporting the anti-vascular effect seen in vivo.

Ort, förlag, år, upplaga, sidor
International Institute of Anticancer Research, 2015. Vol. 35, nr 11, s. 5813-5820
Nyckelord [en]
Electrochemotherapy, bleomycin, head and neck cancer, squamous cell carcinoma, fibroblasts, endothelial cells, selectivity
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
Onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-46832ISI: 000363794900010PubMedID: 26504002Scopus ID: 2-s2.0-84946055559OAI: oai:DiVA.org:oru-46832DiVA, id: diva2:874535
Anmärkning

Funding Agency:

Örebro County Council

Tillgänglig från: 2015-11-27 Skapad: 2015-11-27 Senast uppdaterad: 2018-07-02Bibliografiskt granskad

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Landström, FredrikIvarsson, Mikaelvon Beckerath, MathiasMöller, Claes

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Landström, FredrikIvarsson, Mikaelvon Sydow, Anita Koskelavon Beckerath, MathiasMöller, Claes
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Institutionen för hälsovetenskap och medicinRegion Örebro län
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