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Adipocytokines in placenta and cord blood in relation to maternal obesity, and foetal and postnatal growth of the child
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Örebro universitet, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0002-5292-4913
2015 (Engelska)Ingår i: Hormone Research in Paediatrics, ISSN 1663-2818, E-ISSN 1663-2826, Vol. 82, nr Suppl. 1, s. 47-48Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Abstract [en]

Background: The nutritional and hormonal state in utero may be a link between maternal obesity and obesity in the offspring. The gene expression in placentae in pregnancies complicated by diabetes is reduced for leptin, but increased for ghrelin. It is not known whether these genes’ expressions in placentae are altered in maternal obesity.

Objectives and hypotheses: To compare obese and normal-weight women and their children concerning gene expressions of leptin and ghrelin in placentae; leptin, ghrelin, adiponectin, and C-peptide levels in cord blood, birth size and postnatal growth. Changes in the expression of these adipocytokines may lead to an altered hypothalamic sensitivity to leptin and ghrelin resulting in an increased risk of obesity in the offspring.

Method: 32 women with pre-pregnancy obesity, but otherwise healthy, were compared to 32 matched, normal-weight controls. Full-term placenta biopsies were analysed with qPCR for leptin mRNA and ghrelin mRNA. Cord blood samples were examined with ELISA for leptin, ghrelin, adiponectin, and C-peptide concentrations. Birth size and postnatal growth of the children were collected from clinical registers at the Child Health Care Units.

Results: The leptin and ghrelin gene expressions in placentae did not differ between obese and normal-weight women. The leptin concentration in cord blood was higher in children of obese mothers (P=0.021). It correlated with birth weight Z-score (r=0.467, P<0.001) and C-peptide level in cord blood (r=0.446, P<0.001). Children of obese women were slightly heavier at birth, but postnatal growth did not differ between groups. Children with birth weight  ≤−0.67 Z-score had higher ghrelin levels in cord blood than heavier children (P=0.042). The leptin level in cord blood correlated negatively with weight gain at 6 months (r=−0.332, P=0.009). The ghrelin level in cord blood correlated with weight gain at 3 months in girls (r=0.611, P=0.001), but not in boys. The adiponectin level in cord blood correlated negatively with length gain at 3 years in the obese group (r=−0.571, P=0.033), but not in the normal-weight group.

Conclusion: Leptin and ghrelin placental gene expressions are not altered in obese women, but foetal adipocytokine production may influence early postnatal growth, possibly by influencing hunger signalling or insulin levels

Ort, förlag, år, upplaga, sidor
Basel, Switzerland: S. Karger, 2015. Vol. 82, nr Suppl. 1, s. 47-48
Nyckelord [en]
Obesity, ghrelin, leptin, adipocytokines, growth
Nationell ämneskategori
Medicin och hälsovetenskap Pediatrik
Forskningsämne
Pediatrik
Identifikatorer
URN: urn:nbn:se:oru:diva-49275OAI: oai:DiVA.org:oru-49275DiVA, id: diva2:911183
Konferens
54th Annual ESPE (European Society for Paediatric Endocrinology) Meeting in Barcelona, Spain, 1-3 October 2015.
Tillgänglig från: 2016-03-11 Skapad: 2016-03-11 Senast uppdaterad: 2017-11-30Bibliografiskt granskad

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http://abstracts.eurospe.org/hrp/0084/hrp0084fc8.5.htm

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Allbrand, MarianneÅman, JanLodefalk, Maria

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Hormone Research in Paediatrics
Medicin och hälsovetenskapPediatrik

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