oru.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
PKC, ERK/p38 MAP kinases and NF-κB targeted signalling plays a crucial role in expression and release of IL-1β and CXCL8 in Porphyromonas gingivalis infected monocytes
Örebro universitet, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0001-7105-0425
Örebro universitet, Institutionen för medicinska vetenskaper.
Örebro universitet, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0002-9635-0341
Örebro universitet, Institutionen för medicinska vetenskaper.
Vise andre og tillknytning
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Forskningsprogram
Biomedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-49455OAI: oai:DiVA.org:oru-49455DiVA, id: diva2:913776
Tilgjengelig fra: 2016-03-22 Laget: 2016-03-22 Sist oppdatert: 2018-01-10bibliografisk kontrollert
Inngår i avhandling
1. Monocyte and Neutrophil Inflammatory Responses to the Periodontopathogen Porphyromonas gingivalis
Åpne denne publikasjonen i ny fane eller vindu >>Monocyte and Neutrophil Inflammatory Responses to the Periodontopathogen Porphyromonas gingivalis
2016 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Periodontitis is one of the most common adult infections. Duing bacteremia in healthy individuals or patients with chronic periodontitis, a number of oral bacteria such as Porphyromonas gingivalis encounter inflammatory cells in the blood eg. platelets, neutrophils and monocytes. Although several studies have suggested an association between periodontitis and cardiovascular diseases, the infection and inflammatory mechanisms are poorly understood. Hence, the aim of this thesis was to elucidate the mechanisms that are involved in P. gingivalis interaction with blood leukocytes, in order to further understand the molecular pathogenesis that renders periodontitis as a risk factor for several systemic conditions. We have demonstrated that P. gingivalis induces ROS production in neutrophils, THP1 cells and in whole blood, through activation of pattern recognition receptors, such as toll-like receptors, nuclear oligomerizing domains and protease- activated receptors. Besides, we have also shown that monocytes secrete IL-1β and CXCL8 in response to P. gingivalis. Both these cytokines prime neutrophils, endothelial cells and other vascular cells in an autocrine and paracrine manner. P. gingivalis has a plethora of virulence factors of which gingipains are very unique. In addition to activating inflammatory signalling pathways in cells, gingipains also regulate CXCL8 and IL-1β, thereby curtailing the host defence strategies. We demonstrated that oxidized LDL, but not native LDL, induces IL-1β release and CD36 expression on THP1 cells. Furthermore, LDL mildly modifies P. gingivalis-induced inflammatory responses as well as CD36 expression in THP1 cells. We also observed that P. gingivalis is eliminated mainly by phagocytosis in neutrophils. In summary, these studies clarify the mechanisms of interaction between P. gingivalis and leukocytes, which can increase the understanding of the pathogenesis of periodontitis and associated systemic disorders.

sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2016. s. 63
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 138
Emneord
Monocytes, Neutrophils, Porphyromonas gingivalis, Gingipains
HSV kategori
Forskningsprogram
Biomedicin
Identifikatorer
urn:nbn:se:oru:diva-48228 (URN)978-91-7529-122-2 (ISBN)
Disputas
2016-04-15, Universitetssjukhuset, hörsal C2, Södra Grev Rosengatan, Örebro, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2016-02-12 Laget: 2016-02-12 Sist oppdatert: 2018-01-10bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Personposter BETA

Jayaprakash, KartheyaeneDemirel, IsakGunaltay, SezinKhalaf, HazemBengtsson, Torbjörn

Søk i DiVA

Av forfatter/redaktør
Jayaprakash, KartheyaeneDemirel, IsakGunaltay, SezinKhalaf, HazemBengtsson, Torbjörn
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 539 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf