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Differences in CD14 and alpha-naphthyl acetate esterase positivity and relation to prognosis in AML
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden.
Department of Internal Medicine, Örebro Medical Center Hospital, Örebro, Sweden.
Department of Internal Medicine, Örebro Medical Center Hospital, Örebro, Sweden.
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
1998 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 22, no 1, p. 25-30Article in journal (Refereed) Published
Abstract [en]

Alpha-naphthyl acetate esterase (ANAE) and CD14 expression, used for determination of monocytic cells, were compared and related to prognosis in 65 AML patients. Bone marrow aspiration material from AML patients has been used for the cytochemistry as well as flow cytometry. All non-erythroid cells have been included in the evaluation in both methods. 17/65 cases showed at least 15% difference between the proportion CD14 and ANAE positive cells. Cases with 20% or more CD14 positivity had poorer prognosis. For FAB classes M0-M3, presence of 10% or more CD14 was negative for overall survival (P = 0.01). ANAE did not show significant prognostic influence.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Elsevier, 1998. Vol. 22, no 1, p. 25-30
Keywords [en]
CD14, esterase, acute non-lymphocytic leukemia, prognosis
National Category
Hematology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49522DOI: 10.1016/S0145-2126(97)00100-8ISI: 000073169100005PubMedID: 9585076Scopus ID: 2-s2.0-0031971857OAI: oai:DiVA.org:oru-49522DiVA, id: diva2:914802
Available from: 2016-03-25 Created: 2016-03-25 Last updated: 2017-11-30Bibliographically approved

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Åström, MariaTidefelt, UlfKarlsson, Mats G.

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