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Upregulation of nucleoporin 88 is associated with nodal metastasis and poor differentiation in oral squamous cell carcinoma
Örebro universitet, Institutionen för medicinska vetenskaper.
Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Stomatology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
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2016 (Engelska)Ingår i: International Journal of Clinical and Experimental Medicine, ISSN 1940-5901, E-ISSN 1940-5901, Vol. 9, nr 5, s. 8399-8404Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Nucleoporin 88 (Nup 88) is a component of the nuclear pore complexes (NPCs) that mediates nucleocytoplasmic trafficking of macromolecules, Nup 88 has been reported to be up-regulated in a wide variety of malignancies. Studies show that overexpression of this antigen is associated with the development, agressiveness, differentiation and prognosis in some tumours. Since no study has been carried out in the relationship between the Nup 88 expression and clinicopathological features in the patients with oral squamous cell carcinoma (OSCC), this study aimed to determine Nup 88 expression in OSCC and its clinicopathological significance. Nup 88 expression was examined by immunohistochemistry in 20 normal oral mucosa specimens and 83 OSCC tissues. The frequency of positive Nup 88 expression was gradually increased from normal oral mucosa (10%) to primary OSCC (40%, P=0.012). The Nup 88 positive rate in OSCC patient with nodal metastasis was significantly higher than those without nodal metastasis (64% vs. 21%, P=0.000085). The frequency of positive Nup 88 expression was significantly different between worse and better differentiation (80 vs. 27%, P=0.000024). Nup 88 expression was not related to the patients' gender, age, location and tumour size (P>0.05). In conclusion, Nup 88 may play an important role in tumorigenesis in oral squamous cell carcinoma. Upregulation of Nup 88 is associated with nodal metastasis and poor differentiation in oral squamous cell carcinoma.

Ort, förlag, år, upplaga, sidor
e-Century Publishing , 2016. Vol. 9, nr 5, s. 8399-8404
Nyckelord [en]
Nup 88, metastasis, differentiation, immunohistochemistry, oral squamous cell carcinoma
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-52159ISI: 000379956500090Scopus ID: 2-s2.0-84971382096OAI: oai:DiVA.org:oru-52159DiVA, id: diva2:970691
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Funding Agency:

Health department of Hebei Province, China 20120098

Tillgänglig från: 2016-09-14 Skapad: 2016-09-14 Senast uppdaterad: 2017-11-21Bibliografiskt granskad

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Zhang, Hong

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