Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study
2016 (English)In: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 111, no 10, 1814-1822 p.Article in journal (Refereed) Published
Aims: To investigate the association in males between cognitive ability in late adolescence and subsequent substance misuse-related events, and to study the underlying genetic and environmental correlations.
Design: A population-based longitudinal study with three different family-based designs. Cox proportional hazards models were conducted to investigate the association at the individual level. Bivariate quantitative genetic modelling in (1) full brothers and maternal half-brothers, (2) full brothers reared together and apart and (3) monozygotic and dizygotic twin brothers was used to estimate genetic and environmental correlations.
Setting: Register-based study in Sweden.
Participants: The full sample included 1 402 333 Swedish men born 1958-91 and conscripted at mean age 18.2 [standard deviation (SD) = 0.5] years. A total of 1 361 066 men who had no substance misuse events before cognitive assessment at mandatory military conscription were included in the Cox regression models, with a follow-up time of up to 35.6 years.
Measures Cognitive ability was assessed at conscription with the Swedish Enlistment Battery. Substance misuse events included alcohol- and drug-related court convictions, medical treatments and deaths, available from governmental registries.
Findings: Lower cognitive ability in late adolescence predicted an increased risk for substance misuse events [hazard ratio (HR) for a 1-stanine unit decrease in cognitive ability: 1.29, 95% confidence interval (CI) = 1.29-1.30]. The association was somewhat attenuated within clusters of full brothers (HR = 1.21, 95% CI = 1.20-1.23). Quantitative genetic analyses indicated that the association was due primarily to genetic influences; the genetic correlations ranged between -0.39 (95% CI = -0.45, -0.34) and -0.52 (95% CI -0.55, -0.48) in the three different designs.
Conclusions: Shared genetic influences appear to underlie the association between low cognitive ability and subsequent risk for substance misuse events among Swedish men.
Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2016. Vol. 111, no 10, 1814-1822 p.
Cognitive ability, family study, longitudinal study, quantitative genetic analysis, register-based research, substance misuse
Substance Abuse Psychiatry
IdentifiersURN: urn:nbn:se:oru:diva-52750DOI: 10.1111/add.13440ISI: 000383713500025PubMedID: 27106532ScopusID: 2-s2.0-84986183424OAI: oai:DiVA.org:oru-52750DiVA: diva2:1010379
FunderSwedish Research Council, 2011-2492EU, FP7, Seventh Framework Programme, 602768
Academy of Finland
Swedish Research Council for Health, Working Life and Welfare 2012-1678
Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) 340-2013-58672016-10-032016-10-032016-11-25Bibliographically approved