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Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study
Department of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Stockholm, Sweden; Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Department of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Stockholm, Sweden; Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Neuroscience, Uppsala University, Uppsala, Sweden; Centre for Ethics, Law and Mental Health (CELAM), University of Gothenburg, Mölndal, Sweden; Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenbrug, Sweden.
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2016 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432Article in journal (Refereed) Epub ahead of print
Abstract [en]

Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973-2009, and their 96,557 non-ASD relatives. ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. The risk of substance use-related problems was the highest among individuals with ASD and ADHD. Further, risks of substance use-related problems were increased among full siblings of ASD probands, half-siblings and parents. We conclude that ASD is a risk factor for substance use-related problems. The elevated risks among relatives of probands with ASD suggest shared familial (genetic and/or shared environmental) liability.

Place, publisher, year, edition, pages
New York, USA: Springer, 2016.
Keyword [en]
Autism spectrum disorder, addiction, ADHD, intellectual disability, ICD
National Category
Psychiatry
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URN: urn:nbn:se:oru:diva-53041DOI: 10.1007/s10803-016-2914-2PubMedID: 27734228OAI: oai:DiVA.org:oru-53041DiVA: diva2:1038674
Available from: 2016-10-19 Created: 2016-10-19 Last updated: 2016-10-19Bibliographically approved

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