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Human Intestinal Barrier Function in Health and Disease
Örebro University, School of Medical Sciences. (Nutrition–Gut–Brain Interactions Research Centre)ORCID iD: 0000-0003-0466-1861
Host–Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands.
Metabolism and Nutrition Research Group, WELBIO—Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium.
Nutrition and Health Research, Nestlé Research Center, Lausanne, Switzerland.
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2016 (English)In: Clinical and Translational Gastroenterology, ISSN 2155-384X, E-ISSN 2155-384X, Vol. 7, no 10, e196Article, review/survey (Refereed) Published
Abstract [en]

The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed. In addition, the effect of the frequently prescribed drugs proton pump inhibitors and non-steroidal anti-inflammatory drugs on intestinal permeability, as well as commonly used methods to assess barrier function will be reviewed.

Place, publisher, year, edition, pages
New York: Nature Publishing Group, 2016. Vol. 7, no 10, e196
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-53247DOI: 10.1038/ctg.2016.54ISI: 000391816200003PubMedID: 27763627OAI: oai:DiVA.org:oru-53247DiVA: diva2:1039790
Note

Funding Agency:

ILSI Europe Probiotics Task Force

Available from: 2016-10-25 Created: 2016-10-24 Last updated: 2017-02-13Bibliographically approved

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