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Epigenetic changes as prognostic predictors in endometrial carcinomas
Örebro University, School of Health Sciences. Department of Laboratory Medicine,.
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-5063-631X
Örebro University, School of Health Sciences.
2016 (English)In: Epigenetics, ISSN 1559-2294, E-ISSN 1559-2308Article in journal (Refereed) Accepted
Abstract [en]

Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.

Place, publisher, year, edition, pages
New York, USA: Taylor & Francis, 2016.
Keyword [en]
Endometrial cancer, DNA methylation, prognosis, FIGO grade
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-53666DOI: 10.1080/15592294.2016.1252891PubMedID: 27874289OAI: oai:DiVA.org:oru-53666DiVA: diva2:1050129
Available from: 2016-11-28 Created: 2016-11-28 Last updated: 2016-11-28Bibliographically approved

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Farkas, Sanja A.Sorbe, Bengt G.
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