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Homeostasis of the Gut Barrier and Potential Biomarkers
Host-Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands.
Örebro University, School of Medical Sciences. Orebro University Hospital. (Nutrition-Gut-Brain Interactions Research Centre)ORCID iD: 0000-0002-0362-0008
Centre Daniel Carasso, Danone Research, Avenue de la Vauve, Palaiseau, France.
Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, United Kingdom.
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2017 (English)In: American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, E-ISSN 1522-1547, Vol. 312, no 3, G171-G193 p.Article in journal (Refereed) Published
Abstract [en]

The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of sIgA and antimicrobial peptides and proteins. With exception of sIgA the expression of these protective barrier factors is largely controlled by innate immune recognition of microbial molecular ligands. Several specialized adaptations and checkpoints are operating in the mucosa to scale the immune response according to the threat and prevent overreaction to the trillions of symbionts inhabiting the human intestine. A healthy microbiota plays a key role influencing epithelial barrier functions. However, perturbation of gut barrier homeostasis can lead to increased inflammatory signaling, increased epithelial permeability and dysbiosis of the microbiota, which are recognized to play a role in the pathophysiology of gastrointestinal disorders. Additionally, the gut-brain signaling may be affected by prolonged mucosal immune activation, leading to increased afferent sensory signaling and abdominal symptoms. In turn, neuronal mechanisms can affect the intestinal barrier partly by activation of the HPA-axis and both mast cell-dependent as well as mast cell- independent mechanisms. Several biomarkers have been used to measure gut permeability and loss of barrier integrity in patients but there remains a need to explore their use in assessing impact of nutritional factors on gut barrier function. Future studies should aim to establish normal ranges of the available biomarkers and their predictive value for gut health in human cohorts.

Place, publisher, year, edition, pages
Bethesda, USA: American Physiological Society , 2017. Vol. 312, no 3, G171-G193 p.
Keyword [en]
Gut barrier, antimicrobial peptides, microbiota, epithelial permeability
National Category
Gastroenterology and Hepatology Physiology
Identifiers
URN: urn:nbn:se:oru:diva-53756DOI: 10.1152/ajpgi.00048.2015ISI: 000395739300002PubMedID: 27908847ScopusID: 2-s2.0-85014703516OAI: oai:DiVA.org:oru-53756DiVA: diva2:1052499
Available from: 2016-12-06 Created: 2016-12-05 Last updated: 2017-05-10Bibliographically approved

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