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Obesity and risk for chronic renal failure
Department of Medical Epidemiology and Biostatistic Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute and Karolinsak University Hospital, Stockholm, Sweden; Department of Urology, Sundsvall Hospital, Sundsvall, Sweden.
The International Epidemiology Institute, Rockville, Maryland, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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2006 (English)In: Journal of the American Society of Nephrology, ISSN 1046-6673, E-ISSN 1533-3450, Vol. 17, no 6, 1695-1702 p.Article in journal (Refereed) Published
Abstract [en]

Few large-scale epidemiologic studies have quantified the possible link between obesity and chronic renal failure (CRF). This study analyzed anthropometric data from a nationwide, population-based, case-control study of incident, moderately severe CRF. Eligible as cases were all native Swedes who were aged 18 to 74 yr and had CRF and whose serum creatinine for the first time and permanently exceeded 3.4 mg/dl (men) or 2.8 mg/dl (women) during the study period. A total of 926 case patients and 998 control subjects, randomly drawn from the study base, were enrolled. Face-to-face interviews, supplemented with self-administered questionnaires, provided information about anthropometric measures and other lifestyle factors. Logistic regression models with adjustments for several co-factors estimated the relative risk for CRF in relation to body mass index (BMI). Overweight (BMI>or=25 kg/m2) at age 20 was associated with a significant three-fold excess risk for CRF, relative to BMI<25. Obesity (BMI>or=30) among men and morbid obesity (BMI>or=35) among women anytime during lifetime was linked to three- to four-fold increases in risk. The strongest association was with diabetic nephropathy, but two- to three-fold risk elevations were observed for all major subtypes of CRF. Analyses that were confined to strata without hypertension or diabetes revealed a three-fold increased risk among patients who were overweight at age 20, whereas the two-fold observed risk elevation among those who had a highest lifetime BMI of >35 was statistically nonsignificant. Obesity seems to be an important-and potentially preventable-risk factor for CRF. Although hypertension and type 2 diabetes are important mediators, additional pathways also may exist.

Place, publisher, year, edition, pages
Philadelphia, USA: Lippincott Williams & Wilkins, 2006. Vol. 17, no 6, 1695-1702 p.
Keyword [en]
Adolescent, Adult, Aged, Body Mass Index, Case-Control Studies, Female, Humans, Kidney Failure, Chronic/*complications/*diagnosis/etiology, Male, Middle Aged, Obesity/*complications, Risk, Sweden
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-48977DOI: 10.1681/ASN.2005060638ISI: 000237891100021PubMedID: 16641153ScopusID: 2-s2.0-33646898442ISBN: 1046-6673 (Print) 1046-6673 (Linking)OAI: oai:DiVA.org:oru-48977DiVA: diva2:1061250
Available from: 2017-01-01 Created: 2016-03-06 Last updated: 2017-01-17Bibliographically approved

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Lindblad, Per
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