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The role of diabetes mellitus in the aetiology of renal cell cancer
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA.
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.
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1999 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 42, no 1, 107-12 p.Article in journal (Refereed) Published
Abstract [en]

To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153852 patients (80005 women and 73847 men). The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total of 267 incidences of renal cell cancer (ICD-7:180.0) occurred in diabetic patients compared with the 182.4 that had been expected. Increased risks were observed in both women (SIR = 1.7, 95% confidence interval, CI = 1.4-2.0) and men (SIR = 1.3; 95 % CI = 1.1-1.6) throughout the duration of follow-up (1-25 years). A higher risk was seen for kidney cancer (ICD-7:180) mortality (SMR = 1.9; 95% CI = 1.7-2.2, women; SMR 1.7, 95% CI = 1.4-1.9, men). In comparison with the general population, patients with diabetes mellitus have an increased risk of renal cell cancer.

Place, publisher, year, edition, pages
New York, USA: Springer, 1999. Vol. 42, no 1, 107-12 p.
Keyword [en]
Age Factors, Aged, Carcinoma, Renal Cell/*epidemiology/*etiology/mortality, Cohort Studies, Confidence Intervals, *Diabetes Complications, Diabetes Mellitus/epidemiology, Female, Humans, Incidence, Inpatients, Kidney Neoplasms/*epidemiology/*etiology/mortality, Male, Middle Aged, Registries, Risk Factors, Sex Characteristics, Sweden/epidemiology
National Category
Cancer and Oncology
URN: urn:nbn:se:oru:diva-48985DOI: 10.1007/s001250051122ISI: 000078261300019PubMedID: 10027588ScopusID: 2-s2.0-0032934505ISBN: 0012-186X (Print) 0012-186X (Linking)OAI: oai:DiVA.org:oru-48985DiVA: diva2:1061264
Available from: 2017-01-01 Created: 2016-03-06 Last updated: 2017-01-16Bibliographically approved

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