The role of diabetes mellitus in the aetiology of renal cell cancer
1999 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 42, no 1, 107-12 p.Article in journal (Refereed) Published
To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153852 patients (80005 women and 73847 men). The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total of 267 incidences of renal cell cancer (ICD-7:180.0) occurred in diabetic patients compared with the 182.4 that had been expected. Increased risks were observed in both women (SIR = 1.7, 95% confidence interval, CI = 1.4-2.0) and men (SIR = 1.3; 95 % CI = 1.1-1.6) throughout the duration of follow-up (1-25 years). A higher risk was seen for kidney cancer (ICD-7:180) mortality (SMR = 1.9; 95% CI = 1.7-2.2, women; SMR 1.7, 95% CI = 1.4-1.9, men). In comparison with the general population, patients with diabetes mellitus have an increased risk of renal cell cancer.
Place, publisher, year, edition, pages
New York, USA: Springer, 1999. Vol. 42, no 1, 107-12 p.
Age Factors, Aged, Carcinoma, Renal Cell/*epidemiology/*etiology/mortality, Cohort Studies, Confidence Intervals, *Diabetes Complications, Diabetes Mellitus/epidemiology, Female, Humans, Incidence, Inpatients, Kidney Neoplasms/*epidemiology/*etiology/mortality, Male, Middle Aged, Registries, Risk Factors, Sex Characteristics, Sweden/epidemiology
Cancer and Oncology
IdentifiersURN: urn:nbn:se:oru:diva-48985DOI: 10.1007/s001250051122ISI: 000078261300019PubMedID: 10027588ScopusID: 2-s2.0-0032934505ISBN: 0012-186X (Print) 0012-186X (Linking)OAI: oai:DiVA.org:oru-48985DiVA: diva2:1061264